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Effects of methylphenidate and d-amphetamine on timing in the rat
Authors:D A Eckerman  D Segbefia  S Manning  G S Breese
Affiliation:University of North Carolina, Chapel Hill 27514.
Abstract:Rats were trained to press a lever for food pellets provided according to a fixed interval 60-sec schedule of reinforcement. Probe trials (peak trials) assessed responding over two-min periods with no pellet delivered. The low rates of responding found early and late in probe trials were increased by methylphenidate and 1.0 mg/kg d-amphetamine (rate-dependent effect). Further, the mean time of responding (peak time) was shortened for both drugs (timing effect).
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