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| 鲍曼不动杆菌对氨基糖苷类药物的耐药机制研究 | |
| 引用本文： | 王玲巧,毛翠,张学锋,吴莉丽. 鲍曼不动杆菌对氨基糖苷类药物的耐药机制研究[J]. 检验医学与临床, 2010, 7(7): 584-584,586 |
| 作者姓名： | 王玲巧 毛翠 张学锋 吴莉丽 |
| 作者单位： | 湖州师范学院医学院创新实验室,浙江,湖州,313000;湖州师范学院医学院创新实验室,浙江,湖州,313000;湖州师范学院医学院创新实验室,浙江,湖州,313000;湖州师范学院医学院创新实验室,浙江,湖州,313000 |
| 基金项目： | 湖州师范学院实验室开放项目(20080012) |
| 摘 要： | 目的探讨鲍曼不动杆菌对氨基糖苷类药物耐药机制。方法K-B法检测19株鲍曼不动杆菌对4种氨基糖苷类药物的敏感性,聚合酶链反应(PCR)检测氨基糖苷类修饰酶基因。结果14株鲍曼不动杆菌携带aacA4基因,检出率为74%。结论aacA4型氨基糖苷类修饰酶是鲍曼不动杆菌对氨基糖苷类药物耐药的重要机制。 |
| 关 键 词： | 鲍曼不动杆菌 氨基糖苷类修饰酶 耐药机制 |
Mechanism of aminoglycoside resistance in acinetobacter baumanii |
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| WANG Ling-qiao,MAO Cui,WU Li-li,ZHANG Xue-feng. Mechanism of aminoglycoside resistance in acinetobacter baumanii[J]. Laboratory Medicine and Clinic, 2010, 7(7): 584-584,586 | |
| Authors: | WANG Ling-qiao MAO Cui WU Li-li ZHANG Xue-feng |
| Affiliation: | WANG Ling-qiao,MAO Cui,WU Li-li,ZHANG Xue-feng.Innovation Laboratory,Medical School of Huzhou Teacher's College,Huzhou Zhejian 313000,China |
| Abstract: | Objective To investigate the drug resistance mechanism of acinetobacter baumanii to aminoglycosides.Methods The antibiotic susceptibility of 19 strains of acinetobacter baumanii were tested by K-B method,while aminioglycoside modifying enzymes coding gene were detected by PCR.Results 14 strains of acinetobacter baumanii carried with aacA4 gene coding aminioglycoside modifying enzymes,and the detection rate was 74%.Conclusion The aminoglycoside modifying enzyme coding by aacA4 gene is an important factor in ... |
| Keywords: | acinetobacter baumanii aminoglycoside modifying enzyme |
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