GP方案治疗晚期非小细胞肺癌临床疗效观察

目的评价国产吉西他滨（GEM）联合顺铂（DDP）治疗晚期非小细胞肺癌的临床疗效及不良反应。方法39例晚期非小细胞肺癌患者应用吉西他滨联合顺铂化疗，吉西他滨1000mg／m^2，静脉滴注30min，d1.8；DDP30mg／m^2，静脉滴注，d2～4，21d为1周期，化疗2～3周期后评价疗效。结果39例患者中，1例CR，15例PR，17例SD，6例PD，总有效率（CR＋PR）为41．0％。鳞癌有效率为38．5％；腺癌有效率为42．3％；Ⅲb期有效率为47．6％，Ⅳ期有效率为33．3％；主要毒副反应为骨髓抑制和胃肠道反应，其中白细胞下降至Ⅲ度者为15．4％，血小板下降至Ⅲ、Ⅳ度者为20．5％，Ⅲ度以上恶心呕吐的发生率为7．7％。结论国产吉西他滨联合顺铂治疗晚期非小细胞肺癌疗效较好，毒副反应较轻，患者耐受良好，值得临床推广。

Curative of Gemcitabine Combined with Cisplatin for Advanced Non-Small Cell Lung Cancer

Objective To evaluate the efficacy and toxicities of gemeitabine combined with cisplatin for advanced non-small cell lung cancer. Methods Thirty-nine patients with advanced non-small cell lung cancer received combined chemotherapy： gemcitabine 1 000 mg/m^2 , infusion during 30 minutes on day 1,8, cisplatin 30 mg/m^2 intravenous drip day 2 to 4. The treatment course was 21 days. Results One case achieved CR and 15 achieved PR, 17 SD and 6 PD. The overall response rate（ CR ＋ PR） was 41.0% The effective rate were 38.5% for squamous cell carcinoma and 42.3% for adenocarcinoma;47.6% in Ⅲb stage, and 33.3% in Ⅳ stage. The main toxicities were myelotoxicity and gastrointestinal reaction, in which grade Ⅲ neutropenia accounted for 15. 4% , grade m-Ⅳ thrombocytopenia for 20. 5% , and grade Ⅲ or more nausea and vomiting for 7. 7%. Conclusion Combination chemotherapy of gemcitabine and eisplatin has a good anti-tumor activity on advanced non-small cell lung cancer with manageable toxicity.