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| Effects of emodin on the proliferation of the glomerular mesangial cell and correlative cytokines in rats | |
| 引用本文： | Xili Wu,Wanggang Zhang,Wansen Sun,Chenglin Qiao. Effects of emodin on the proliferation of the glomerular mesangial cell and correlative cytokines in rats[J]. 南京医科大学学报(自然科学版), 2007, 21(5): 298-301 |
| 作者姓名： | Xili Wu Wanggang Zhang Wansen Sun Chenglin Qiao |
| 作者单位： | [1]Department of Integrated Chinese Traditional and Western Medicine, the Second Affiliated Hospital of Xi＇ an Jiaotong University, Xi＇ an 710004, Shanxi Province, China [2]Department of Hematology, the Second Affiliated Hospital of Xi＇ an Jiaotong University, Xi＇ an 710004, Shanxi Province, China |
| 摘 要： | Objective：To investigate the effects of emodin（EMD） on cell proliferation and correlative cytokines secretion of glomerular mesangial in rats. Methods：The effects of EMD on cell proliferation and IL-6, TGF-β1 secretion of glomerular mesangial in rats were observed. Cell proliferation was measured by MTT method. IL-6 and TGF-β1 secretion was detected with ELISA. Results：EMD was able to inhibit the cell proliferation and down-regulate the IL-6 and TGF-β 1 secretion of glomerular mesangial, as compared to the model group in rats （P 〈 0.05）. Conclusion：EMD could significantly inhibit the cell proliferation, and reduce the creation of extracellular matrix（ECM）, this indicated that it could play an important role in alleviation and prevention of glomerular sclerosis. The mechanism may be that EMD can reduce the IL-6 and TGF-β1 secretion ofglomerular mesangial cell in rats. |
| 关 键 词： | 大黄素 肾小球 细胞增殖 药物疗效 |
| 修稿时间： | 2007-05-29 |
Effects of emodin on the proliferation of the glomerular mesangial cell and correlative cytokines in rats |
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| Xili Wu,Wanggang Zhang,Wansen Sun and Chenglin Qiao. Effects of emodin on the proliferation of the glomerular mesangial cell and correlative cytokines in rats[J]. Acta Universitatis Medicinalis Nanjing, 2007, 21(5): 298-301 | |
| Authors: | Xili Wu Wanggang Zhang Wansen Sun Chenglin Qiao |
| Abstract: | Objective:To investigate the effects of emodin(EMD) on cell proliferation and correlative cytokines secretion of glomerular mesangial in rats. Methods:The effects of EMD on cell proliferation and IL-6 , TGF-β1 secretion of glomerular mesangial in rats were observed. Cell proliferation was measured by MTT method. IL-6 and TGF-β1 secretion was detected with ELISA. Results:EMD was able to inhibit the cell proliferation and down-regulate the IL-6 and TGF-β1 secretion of glomerular mesangial, as compared to the model group in rats (P＜0.05). Conclusion:EMD could significantly inhibit the cell proliferation, and reduce the creation of extracellular matrix(ECM), this indicated that it could play an important role in alleviation and prevention of glomerular sclerosis. The mechanism may be that EMD can reduce the IL-6 and TGF-β1 secretion of glomerular mesangial cell in rats. |
| Keywords: | emodin glomerular mesangial cell mesangial cell proliferation correlative cytokines rats cytokines glomerular mesangial cell cell proliferation emodin mechanism play role alleviation prevention reduce creation extracellular matrix model group able Results ELISA Cell MTT method |
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