| 牛膝精对辐照小鼠造血干细胞和红系造血祖细胞的影响 |
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| 引用本文： | 全宏勋,张宇明,马素好,冯向功,邓爱民,张海林. 牛膝精对辐照小鼠造血干细胞和红系造血祖细胞的影响[J]. 中国辐射卫生, 2011, 20(2): 144-145 |
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| 作者姓名： | 全宏勋 张宇明 马素好 冯向功 邓爱民 张海林 |
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| 作者单位： | 1. 郑州澍青医学高等专科学校,河南,郑州,450064
2. 河南职工医学院 |
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| 摘 要： | 目的探讨牛膝精（ABE）对辐照小鼠造血干细胞（以CFU-S表示）和早期红系造血祖细胞[以红系爆式集落形成单位（BFU-E）表示]和晚期红系造血祖细胞[以晚期红系集落形成单位（CFU-E）表示]的影响。方法采用脾集落形成和造血祖细胞培养技术,观察了牛膝精对辐照小鼠脾重、造血干细胞、早期红系造血祖细胞和晚期红系造血祖细胞的影响。结果该药能使受照鼠脾重及脾集落数明显提高,但不能刺激早、晚期红系造血祖细胞的活性。结论牛膝精能刺激造血干细胞的增殖,但对其向红系分化无明显影响。
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| 关 键 词： | 牛膝精 造血干细胞 早期红系造血祖细胞 晚期红系造血祖细胞 辐照小鼠 |
Effects of Extract of Achynanthis Bidentatae on CFU - S and Hemopoiesis of BFU - E, CFU - E in Irradiated Mice |
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| QUAN Hong-xun,ZHANG Yu-ming,MA Su-hao,et al.. Effects of Extract of Achynanthis Bidentatae on CFU - S and Hemopoiesis of BFU - E, CFU - E in Irradiated Mice[J]. Chinese Journal of Radiological Health, 2011, 20(2): 144-145 |
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| Authors: | QUAN Hong-xun ZHANG Yu-ming MA Su-hao et al. |
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| Affiliation: | QUAN Hong-xun,ZHANG Yu-ming,MA Su-hao,et al. Zhengzhou Shu Qing Medical College,Zhengzhou 450064 China. |
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| Abstract: | Objective To study the Extract of Achynanthis Bidentatae（ABE） on colony forming unit-spleen（CFU-S）and hemopoiesis of burst forming unit-erythroid（BFU-E）、colony forming unit-erythroid（CFU-E） in Irradiated mice.Methods Using techniques of CFU-S and cell culture of hemopoietic progenitors in vitro,the authors observed the effects of ABE on weight of spleen﹑CFU-S﹑BFU-E and CFU-E.Results It is shown the weight of spleen and the number of CFU-S was increased,but there was no stimulation activity on BFU-E and CFU-E.Conclution ABE may stimulate the proliferation of CFU-S,but there was no effect on differentiation of BFU-E and CFU-E. |
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| Keywords: | Extract of Achynanthis Bidentatae(ABE) colony forming unit-spleen(CFU-S) burst forming unit-erythroid(BFU-E) colony forming unit-erythroid(CFU-E) Irradiated mouse |
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