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The influence of some antidepressant drugs on the nuclear volume of rat cingular cortex cells in culture
Authors:A Bal  M Smia?owska
Affiliation:Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Abstract:
The changes in the volume of cell nuclei of the rat cingular cortex were investigated in culture after incubation with some antidepressant drugs. Two-week incubation of the cingular cortex culture with both tricyclic (desipramine, imipramine, amitryptyline) and non-tricyclic (mianserin) antidepressants in concentration of 3 X 10(-6) M resulted in a decrease of the volume of the cell nuclei. Because the size of the nucleus is regarded as a criterion of the cell metabolic activity, our results may point to a diminished activity of metabolic processes of the cells.
Keywords:
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