58例骨髓增生异常综合征的染色体核型分析

目的探讨染色体核型分析在骨髓增生异常综合征（MDS）诊断、预后评估中的价值。方法采用骨髓短期培养法和R显带技术对58例MDS患者进行染色体核型分析，同时追踪其临床病情进展情况。结果58例MDS患者中有31例（53．4％）检出异常克隆。在异常染色体核型中＋8和高度复杂异常最多。58例患者经追踪观察，19例（30．5％）患者转化为急性白血病。结论染色体核型分析在MDS诊断预后评估方面具有重要价值。

Karyotype Analysis of 58 cases myelodysplastie synarom

Objective To explore theralue of karyotype analysis in MDS for diagnosis, cure and progno-sis. Methods Chromosome analysis was performed in 58 cases of MDS using the short-term culture of bone marrow eell and R-banding technique, meanwhile,their clinical progress was followed up. Results Karyotype a-nalysis showed that 31 eases(53.4%) had elonal Karyotypie abnormalities. The nost common chromosomal ab-errations included +8 and high complex karyotypic, and then-7/7q-In the following up, 19 eases (30.5%) transformed into acute leukemia. Conclusion The Karyotype analysis is very important for diagnosis, cure and prognosis of MDS.