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| 吗啡依赖大鼠戒断后心血管活动的改变及机理 | |
| 引用本文： | 朱显武,何巍,王红伟,邱学才. 吗啡依赖大鼠戒断后心血管活动的改变及机理[J]. 中国药物依赖性杂志, 1998, 7(2): 77-80 |
| 作者姓名： | 朱显武 何巍 王红伟 邱学才 |
| 作者单位： | 北京医科大学生理学系,北京,100083 |
| 基金项目： | 北京医科大学天然药物及仿生药物国家重点实验室资助 |
| 摘 要： | 目的：观察吗啡依赖大鼠戒断反应后心血管活动的改变。方法：用递增法制备吗啡依赖大鼠模型，并用纳洛酮催促戒断，在清醒状态下用ＰＳ－１００型大鼠尾动脉血压记录仪记录平均动脉血压（ｍＡＢＰ）和心率（ＨＲ）。结果：吗啡依赖大鼠在纳洛酮催促戒断后ｍＡＢＰ明显升高，并持续３０ｍｉｎ以上。皮下注射可乐定可阻断吗啡依赖大鼠戒断后ｍＡＢＰ的升高，且呈明显的量效关系。结论：吗啡依赖大鼠戒断时ｍＡＢＰ有明显的上升，可乐定可使吗啡戒断时上升的ｍＡＢＰ下降 |
| 关 键 词： | 吗啡依赖；戒断；平均动脉血压；心率；可乐定 |
CHANGES OF CARDIOVASCULAR FUNCTION IN MORPHINE WITHDRAWAL RATS AND ITS MECHANISM |
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| Zhu Xianwu,He Wei,Wang Hongwei,Qiu Xuecai. CHANGES OF CARDIOVASCULAR FUNCTION IN MORPHINE WITHDRAWAL RATS AND ITS MECHANISM[J]. Chinese Journal of Drug Dependence, 1998, 7(2): 77-80 | |
| Authors: | Zhu Xianwu He Wei Wang Hongwei Qiu Xuecai |
| Abstract: | Objective: To observe the changes of cardiovascular activity in morphine withdrawal rats. Method: Established the model of morphine dependent rats by progressively increasing the doses of morphine and determined the mean arterial blood pressure (mAPB) and heart rate (HR) in consciousness rats. Result: The mABP of morphine withdrawal rats was higher than that of unwithdrawal rats, and can be maintained for more than 30 minutes. This hypertensive effect could be inhibited by cutaneously injection of clonidine. Conclusion: Hypertension could be induced in morphine withdrawal rats. The hypertensive syndrome in morphine withdrawal rats could be inhibited by injecting clonidine subcutaneously. |
| Keywords: | morphine dependent mean blood pressure(mABP) heart rate(HR) morphine withdrawal clonidine |
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