帕瑞昔布钠对腰椎手术患者舒芬太尼术后镇痛效果的影响

目的:观察帕瑞昔布钠对腰椎手术患者舒芬太尼术后镇痛效果的影响.方法:择期行腰椎手术的患者40例,随机分为帕瑞昔布钠组和对照组.两组术中采用相同的麻醉方法.帕瑞昔布钠组术前和第1次给药后12 h静注帕瑞昔布钠40 mg,对照组则静注2 ml生理盐水.术后均采用舒芬太尼自控镇痛.观察术后48 h内的视觉模拟评分(VAS评分...

Effects of parecoxib on efficacy of postoperative analgesia of sufentanil after lumbar spine surgery

Objective：To observe the effects of parecoxib on postoperative analgesic efficacy of sufentanil after lumbar spine surgery. Methods： Forty patients undergoning selective lumbar spine surgery were randomly divided into two groups, with 20 patients in each group. Parecoxib group received parecoxib 40 mg and control group re- ceived normal saline 2 ml before induction and 12 hours after the first injection. Pump of self-control analgesic with sufentanil was used for postoperative analgesia. Visual analogue scale （VAS）, consumption and side-effect of sufentanil were recorded at 1 hour, 6 hours, 12 hours, 24 hours and 48 hours after operation. Results：VAS at 6 hours was significantly lower in parecoxib group than in control group （P〈0.05） but no significant difference was found at 12 hours, 24 hours and 48 hours after operation between two groups. The consumption of sulfentanil at 12 hours, 24 hours and 48 hours was significantly lower in parecoxib group than in control group（all P〈0.05）. There was no significant difference in the side--effect of sulfentanil between the two groups. Conclusions： Parecoxib can enhance the postoperative analgesic efficacy of sufentanil after lumba spine surgery and diminish the consumption of sufentanil.