温通巴布膏对腹泻模型鼠的治疗效果

目的探讨温通巴布膏对腹泻模型鼠的治疗效果。方法采用蓖麻油灌胃制备小鼠腹泻模型,将实验动物分为3组,观察并记录腹泻小鼠6 h内大便性状、腹泻次数、体质量变化和贴敷药膏处皮肤反应。结果腹泻＋药物组末次灌胃后6 h内累计稀便次数及体质量下降较单纯腹泻组和腹泻＋基质组均明显减少,差异有显著性（F=4.20、28.35,q=3.02-5.50,P〈0.05、0.01）,而单纯腹泻组和腹泻＋基质组间比较差异无显著性（P〉0.05）;腹泻＋药物组、腹泻＋基质组小鼠贴敷药膏处及全身皮肤无发红、皮疹、水疱和肿胀现象发生。结论温通巴布膏对腹泻模型鼠具有较好的止泻作用,对皮肤无刺激作用。

STUDY OF THE ANTI-DIARRHEA EFFECT OF WENTONGBABUGAO ON MODEL MICE

Objective To study the anti diarrhea effect of Wentongbabugao on model mice. Methods A diarrhea-model mouse was established by intragastric administration of castro oil. The experimental animals were divided into three groups. The stool characteristics, the number of diarrhea, the weight loss of the mice in six hours, and the skin reaction on which the paste was applied were recorded. Results The number of diarrhea, the weight loss in diarrhea-plus-drug group were less than the diarrhea group and diarrhea-plus-base group, the difference was significant （F=4. 20,28. 35,q= 3. 02-5. 50;P〈0. 01,0. 05）. The difference between the diarrhea group and diarrhea plus-base group was not significant （P〉0.05）. No skin reactions such as flush, rash, blain, or swelling was observed in diarrhea-plus drug group and diarrhea plus-base group. Conclusion The Wen tongbabugao is effective on anti diarrhea without irritation to skin.