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| 缺血后处理对大鼠急性心肌缺血再灌注损伤的影响 | |
| 引用本文： | 魏晓霞,肖传实,边云飞. 缺血后处理对大鼠急性心肌缺血再灌注损伤的影响[J]. 中西医结合心脑血管病杂志, 2011, 9(6): 701-702 |
| 作者姓名： | 魏晓霞 肖传实 边云飞 |
| 作者单位： | 1. 山西医科大学第二医院,030001 2. 山西医科大学第二医院 |
| 摘 要： | 目的观察在体条件下缺血后处理对大鼠心肌缺血再灌注损伤的作用及可能的途径。方法建立大鼠在体缺血再灌注模型,将30只大鼠随机分为假手术组、缺血再灌注组、缺血后处理组、缺血预适应组。于再灌注末测定心肌酶,超氧化物歧化酶(SOD)及丙二醛(MDA)的含量,并测定心肌组织梗死面积。结果与缺血再灌注组相比,缺血后处理组与缺血预适应组心肌梗死面积明显减小,血浆肌钙蛋白I及MDA的含量均降低(P<0.05),血浆SOD活性升高(P<0.05)。结论缺血后处理可减轻心肌缺血再灌注损伤,具有心肌保护效应。 |
| 关 键 词： | 心肌 缺血再灌注损伤 缺血后处理 |
Effects of Ischemic Postconditioning on Rat Hearts with Acute Myocardial Ischemia-Reperfusion Injury |
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| Wei Xiaoxia,Xiao Chuanshi,Bian Yunfei. Effects of Ischemic Postconditioning on Rat Hearts with Acute Myocardial Ischemia-Reperfusion Injury[J]. Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease, 2011, 9(6): 701-702 | |
| Authors: | Wei Xiaoxia Xiao Chuanshi Bian Yunfei |
| Affiliation: | Wei Xiaoxia,Xiao Chuanshi,Bian Yunfei Department of Cardiology,The Second Hospital of Sanxi University Medical College(Taiyan 030002) |
| Abstract: | Objective To investigate the effects and the way of ischemic postconditioning on ischemia reperfusion injury of rats in vivo.Methods Thirty Wistar rats were randomly divided into four groups:Sham operation group,ischemia-reperfusion group,ischemic preconditioning group,ischemic postconditioning group.Cardiac treponin I(cTnI),malonaldehyde(MDA),superoxide dismutase(SOD) in plasma were tested with biochemistry technique,myocardial infarct size was measured by image analytical system.Results Compared with IR g... |
| Keywords: | myocardium ischemia-reperfusion injury ischemic postconditioning |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |