茎叶人参皂甙和维生素E对百草枯所致大鼠急性肺损伤保护作用的比较研究

目的研究茎叶人参皂甙和维生素E（VE）对百草枯所致大鼠急性肺损伤（ALI）的保护作用。方法采用百草枯所致大鼠急性肺损伤模型，随机分为正常对照组（NS组）、肺损伤组（ALI组）、维生素E干预组（VE组）和皂甙干预组（GS组）。观察皂甙和VE对大鼠急性肺损伤时MDA等水平、病理改变及肺系数等影响。结果GS组和VE组可明显降低肺损伤所致血浆、组织中MDA等水平的升高，并能降低肺系数；同时又能显著升高肺组织中SOD、GSH-PX的水平，且GS组和VE组之间差异无统计学意义（P〉0.05）。结论茎叶人参皂甙和VE可通过抑制MDA的表达，改善SOD、GSH-PX等方式减少氧自由基的产生，减轻肺损伤程度，对百草枯所致急性肺损伤有明显的保护作用。

Comparision study on the effect of ginsenoside and vitamin E against acute lung injure in rat

Objective To compare the effect of ginsenoside and vitamin E against acute lung injury in rat. Methods Using acute lung injury rat induced by parquat, rats were randomly divided into four groups： control group （ NS group ）, parquet group （ALI group）, ginsenoside pretreatment group （ GS group）, and vitamin E pretreatment group （VE group）. Malandialdehyde （MDA）, superoxide dismutase （SOD）, glutathione peroxidase （ GSH-PX）, lung coefficient and the pathological slices were detected. Results Comparing with the control group,the lung coefficient, MDA were obviously down-regulated by ginsenoside and vitamin E. Ginsenoside and vitamin E significient increased the level of SOD and GSH-PX. Conclusions Ginsenoside and vitamin E might inhibit the level of MDA and increase the level of SOD and GSH-PX, and reduce releasing of free radicals. Hence panaxoside and vitamin E had a protective effect on acute lung injury.