|
|||||
|
|
| 白介素6、肿瘤坏死因子α在脊髓型颈椎病发病中的作用 | |
| 引用本文： | 刘自金. 白介素6、肿瘤坏死因子α在脊髓型颈椎病发病中的作用[J]. 中国基层医药, 2010, 17(11): 1464-1465. DOI: 10.3760/cma.j.issn.1008-6706.2010.11.011 |
| 作者姓名： | 刘自金 |
| 作者单位： | 肥城矿业中心医院骨科,山东省肥城,271608 |
| 摘 要： | 目的 检测脊髓型颈椎病患者颈椎间盘组织中白细胞介素6（IL-6）和肿瘤坏死因子α（TNV-α）的水平,探讨IL-6和TMF-α在脊髓型颈椎病（CSM）发病机制中的作用.方法收集40例手术治疗的CSM患者的退变椎间盘组织,取20例正常椎间盘组织作为对照,匀浆后取上清液,ELISA法检测IL-6和TNF-α的含量.结果 CSM组颈椎间盘组织内IL-6、TNF-α的水平均明显高于对照组,差异有统计学意义（P〈0.01）.结论 CSM患者的颈椎间盘组织内IL-6和TNF-a的含量明显增高,它们可能在脊髓型颈椎病的发病机制中发挥重要作用. |
| 关 键 词： | 脊髓型颈椎病 白介素6 肿瘤坏死因子α |
Effect of IL-6 and TNF-a in the Cervical Spondylotic Myelopathy |
|
| LIU Zi-jin. Effect of IL-6 and TNF-a in the Cervical Spondylotic Myelopathy[J]. Chinese Journal of Primary Medicine and Pharmacy, 2010, 17(11): 1464-1465. DOI: 10.3760/cma.j.issn.1008-6706.2010.11.011 | |
| Authors: | LIU Zi-jin |
| Affiliation: | LIU Zi-fin. (Department of Orthopaedics ,The Colliery Central Hospital of Feicheng City, Shandong 271608, China) |
| Abstract: | Objective To measure the levels of interleukin-6 (IL-6) and tumor necrosis factor-a( TNF-a) in the cervical intervertebral disk of patients with cervical spondylotic myelopathy ( CSM) ,study the role of IL-6 and TNF-a in the pathogenesis of CSM.Methods 40 degenerative cervical vertebral disk tissues were collected from CSM cases;20 normal tissues of vertebral disk were taken as control.The contents of IL-6 and TNF-a were detected by ELISA.Results The contents of IL-6 and TNF-a in disk of CSM sufferers increased significantly compared with the control group (P<0.01).Conclusion The results of the present study indicated that IL-6 and TNF-a may be involved in the pathogenesis of CSM. |
| Keywords: | Cervical spondylotic myelopathy IL-6 TNF-a |
| 本文献已被 维普 万方数据 等数据库收录！ | |