| B(a)P诱导小鼠前胃癌过程中组织病理学变化 |
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| 引用本文： | 张晓峰,李百祥. B(a)P诱导小鼠前胃癌过程中组织病理学变化[J]. 中国癌症杂志, 2004, 14(5): 422-424 |
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| 作者姓名： | 张晓峰 李百祥 |
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| 作者单位： | 哈尔滨医科大学公共卫生学院卫生毒理学教研室,黑龙江,哈尔滨,150001 |
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| 基金项目： | 黑龙江省高校骨干教师创新能力资助项目 |
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| 摘 要： | 目的：探讨B(a)P诱导小鼠前胃癌过程中胃组织形态学的动态改变。方法：小鼠用5mg／ml的B(a)P灌胃，每周两次，共4周。以后每隔4周处死一部分小鼠，对胃组织进行病理组织学观察。结果：从第17周开始小鼠前胃开始出现肉眼可见的肿瘤，前胃组织由局部腺体增生、排列紊乱逐步发展为腺体普遍异常增生，形成早期胃癌，进一步发展出现进展期胃癌。结论：B(a)P诱导的小鼠前胃癌的潜伏期大约3个月左右，前胃组织病理学动态变化过程是萎缩性胃炎、不典型增生、胃癌。
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| 关 键 词： | 苯并（a）芘 前胃癌 不典型增生 小鼠 |
| 文章编号： | 1007-3639(2004)05-0422-03 |
| 修稿时间： | 2004-06-14 |
Study on histopathology of the mouse forestomach neoplasm inducd by B(a)P |
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| ZHANG Xiao-feng,LI Bai-xiang. Study on histopathology of the mouse forestomach neoplasm inducd by B(a)P[J]. China Oncology, 2004, 14(5): 422-424 |
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| Authors: | ZHANG Xiao-feng LI Bai-xiang |
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| Abstract: | Purpose:To explore the development change of histopathology of the mouse forestomach neoplasm inducd by B(a)P.Methods:A part of the mice were killed each four weeks after they were given benzo(a)pyrene (concentration 5mg/ml) by lavage for four weeks, twice per week. The histopathology of the forestomach was then observed.Results:Forestomach neoplasm was noticed from the 17~(th) week in the mice. Local gland hyperplasia, arrangement disorder gradually developing into glandular abnormality hyperplasia and then transformed into early stomach cancer and finally into aggressive stomach cancer could be observed.Conclusions:Latent period of the mouse forestomach neoplasm induced by B(a)P is about three months. The development course is atrophic gastritis, atypical hyperplasia and stomach cancer.[ |
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| Keywords: | benzo(a)pyrene forestomach neoplasia atypical hyperplasia mouse |
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