Vasopressin analogues and V1a receptor agonists in septic shock |
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| Authors: | Marc O. Maybauer Dirk M. Maybauer |
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| Affiliation: | (1) Division of Critical Care Medicine, Department of Anesthesiology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0591, USA;(2) Department of Anaesthesiology and Intensive Care Medicine, Philipps University of Marburg, Baldinger Strasse 1, 35043 Marburg, Germany |
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| Abstract: | This article reviews the role of arginine-vasopressin and the vasopressin analogue terlipressin as potent alternative vasoconstrictors in the treatment of fluid and catecholamine-refractory septic shock. Terlipressin is the most selective, clinically available V1 receptor agonist, and may be more potent than arginine-vasopressin in restoring catecholamine refractory septic shock. Recent experimental and clinical studies on terlipressin, as well as the possible benefit of selective V1a receptor agonists, are discussed. |
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