氨氯地平联合贝前列素钠治疗高血压早期肾损害临床研究

目的探讨氨氯地平联合贝前列素钠治疗高血压早期肾损害的疗效,以及对患者β2微球蛋白(β2-MG)、胱抑素C(CysC)、同型半胱氨酸(HCY)和尿微量白蛋白(m ALB)的影响。方法选取医院2017年5月至2018年5月接诊的高血压合并早期肾损害患者98例,按治疗方式不同分为治疗组和对照组,各49例。两组患者均给予常规基础治疗及苯磺酸氨氯地平片治疗,在此基础上,治疗组患者给予贝前列素钠片治疗。两组患者均治疗2个月。结果治疗后,两组患者的收缩压(DBP)和舒张压(SBP)均下降,且治疗组明显低于对照组(P <0. 05);两组患者的β2-MG,CysC,m ALB,HCY均下降,且治疗组显著低于对照组(P <0. 05);两组患者的白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)和超敏C反应蛋白(hs-CRP)水平均下降,且治疗组显著低于对照组(P <0. 05);治疗组不良反应发生率为6. 12%,与对照组的12. 24%相当(P> 0. 05)。结论氨氯地平联合贝前列素钠对高血压合并早期肾损害患者的肾脏保护作用更显著,其机制可能与稳定血压和抑制炎性反应有关,且安全性较高。

Amlodipine Combined with Beraprost Sodium for Early Renal Damage Induced by Hypertension

Objective To investigate the effect of amlodipine combined with beraprost sodium on β2-microglobulin( β2-MG),cystatin C( CysC),homocysteine( Hcy) and urinary microalbumin( m ALB) for early renal damage induced by hypertension. Methods The clinical data of 98 patients with hypertension complicated with early renal damage from May 2017 to May 2018 were collected and divided into the treatment group and the control group according to different treatment methods,49 cases in each group. Both groups were given routine basic treatment and amlodipine, while on this basis the treatment group was added with beraprost sodium. Both groups were treated for 2 months. Results After treatment,the systolic blood pressure( DBP) and diastolic blood pressure( SBP) values in the two groups decreased,and the treatment group was significantly lower than the control group( P < 0. 05);the levels of β2-MG,CysC,m ALB and Hcy in the two groups decreased,and the levels in the treatment group were significantly lower than those in the control group( P < 0. 05);the levels of interleukin-6( IL-6),tumor necrosis factor-α( TNF-α) and hypersensitive C-reactive protein( hs-CRP) in the two groups decreased,and the levels in the treatment group were significantly lower than those in the control group( P < 0. 05). The total incidence of adverse reactions in the treatment group was 6. 12%,which had no significant difference compared with 12. 24% in the control group( P > 0. 05). Conclusion Amlodipine combined with beraprost sodium has a more significant protective effect on kidney in patients with hypertension complicated with early renal damage. Its mechanism may be related to stabilizing blood pressure and inhibiting inflammation,and its safety is relatively high.