| 应激大鼠肾脏中MDA含量及GSH-px、CAT和Ca~(2 )-ATPase活性的变化 |
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| 引用本文： | 陆任云,许燕.应激大鼠肾脏中MDA含量及GSH-px、CAT和Ca~(2 )-ATPase活性的变化[J].江苏大学学报(医学版),1998(3). |
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| 作者姓名： | 陆任云 许燕 |
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| 摘 要： | 通过观察大鼠在应激状态下肾脏中丙二醛（ＭＤＡ）含量以及谷胱甘肽过氧化物酶（ＧＳＨ－ｐｘ）、过氧化氢酶（ＣＡＴ）和钙泵（Ｃａ２＋－ＡＴＰａｓｅ）活性的变化。结果显示：在应激状态下，肾脏ＭＤＡ的含量在应激２ｈ后迅速并持续升高，ＣＡＴ和Ｃａ２＋－ＡＴＰａｓｅ活性增加高峰均在应激２ｈ时，之后又有所下降，但依然显著高于对照组，ＧＳＨ－ｐｘ活性也有所升高，但只在应激２ｈ时显著高于对照组。结果提示：在应激状态下，肾脏的脂质过氧化作用加强，抗氧化能力和清除细胞内Ｃａ２＋能力在应激一定时间内（２ｈ）代偿性加强后又有所下降
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| 关 键 词： | 应激 肾脏 MDA GSH－px CAT Ca~(2＋)－ATPase |
Changes of Content of MDA and Activity of GSH-px CAT and Ca 2 -ATPase in Rat Kidneg Under Stress |
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| Lu Renyun.Changes of Content of MDA and Activity of GSH-px CAT and Ca 2 -ATPase in Rat Kidneg Under Stress[J].Journal of Jiangsu University Medicine Edition,1998(3). |
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| Authors: | Lu Renyun |
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| Institution: | Lu Renyun (Department of Biochemistry) Xu Yan (Department of Pathophosiology) |
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| Abstract: | Using the stress model of bound and soaked rat, we observed the changes of the content of MDA and the activity of glutathione peroxidase (GSH-px),catalase(CAT) and Ca 2 -ATPase in the rat kidney.The results showed that the content of MDA increased remarkably and lastingly under shrss for 2 hours and so did the activity of CAT and Ca 2 -ATPase.But as stress time was prolonged to 3 hours, the activity decreased but still remained higher remarkably thom the control; the activity of GSH-px increased remarkably under stress for only 3 hours.These results indicated that the action of lipid peroxide was strengthened while the action of antioxidation and calcium- clearing was enhanced compensatedly,but then decreased. |
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| Keywords: | stress kidney MDA GSH-px CAT Ca 2 -ATPase |
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