| Changes of intracellular calcium and the correlation with functional damage of the spinal cord after spinal cord injury |
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| 引用本文： | 章亚东,侯树勋,吴叶. Changes of intracellular calcium and the correlation with functional damage of the spinal cord after spinal cord injury[J]. 中华创伤杂志(英文版), 2002, 5(1): 40-42 |
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| 作者姓名： | 章亚东 侯树勋 吴叶 |
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| 作者单位： | DepartmentofOrthopedics,304thHospitalofPLA,Beijing100037 |
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| 摘 要： |
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| 关 键 词： | 脊髓神经损伤 细胞内钙离子 动物实验 改良Allen法 |
Changes of intracellular calcium and the correlation with functional damage of the spinal cord after spinal cord injury |
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| Yadong Zhang,Shuxun Hou,Ye Wu. Changes of intracellular calcium and the correlation with functional damage of the spinal cord after spinal cord injury[J]. Chinese journal of traumatology, 2002, 5(1): 40-42 |
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| Authors: | Yadong Zhang Shuxun Hou Ye Wu |
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| Affiliation: | Department of Orthopedics, 304th Hospital of PLA, Beijing 100037, China |
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| Abstract: | OBJECTIVE: To observe dynamic changes of intracellular calcium ([Ca(2+)]i) after spinal cord injury, and to study the relationship between the changes of [Ca(2+)]i and the functional damage of the spinal cord. METHODS: The rats were subjected to a spinal cord contusion by using a modified Allen's method. The [Ca(2+)]i in the injured segment of the spinal cord was measured by the technique of La(3+) blockage and atomic absorption spectroscopy at 1, 4, 8, 24, 72, and 168 hours after injury. The motor function on the inclined plane was measured at the same time. RESULTS: The spinal cord [Ca(2+)]i increased significantly (P<0.05 or P<0.01) aft er spinal cord injury. There was a significant correlation (P<0.05) between the changes of [Ca(2+)]i and the motor function. CONCLUSIONS: [Ca(2+)]i overload may play an important role in the pathogenesis of spinal cord injury. |
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| Keywords: | Spinal cord injuries Calcium Rats |
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