肝脏恶性肿瘤MR灌注成像的灌注量化分析

目的初步探讨应用MRI灌注技术对肝脏恶性肿瘤占位性病变灌注系数进行量化分析的价值。方法选取临床确诊的肝脏恶性肿瘤（原发性肝癌、转移性肝癌）病例共28例（52个病灶），采用2DFSPGR序列动态增强首过期灌注成像技术进行MRI灌注成像研究。计算肝脏灌注系数（HPI）并进行分组比较，利用各组肝脏恶性肿瘤HPI分布特征，选择MRI灌注量化诊断的参考标准。结果所有病变的HPI均高于正常肝组织组。原发性肝癌的HPI明显高于转移性肝癌。应用HPI≥0.7作为鉴别原发性肝癌与转移性肝癌的诊断指标，具有较高的敏感度，特异度及准确度。结论MR灌注成像技术可以对肝脏恶性肿瘤的进行量化分析，反应其血流灌注特点，有助于常见肝脏恶性肿瘤的诊断及鉴别诊断。

Uantity Analysis of Hepatic Perfusion in Liver Occupying Lesion by Using MR Perfusion Imaging

Objective To use dynamic eontrast-enhaneed（DCE）MR imaging to quantify the HPI of primary hepatic carcinoma, metastases. Methods Total 30 patients with 52 liver occupying lesions underwented MRI perfusion imaging, including 22（30masses） primary hepatic carcinoma, 8（22masses） second malignant tumor.The median HPIs of different kinds of liver occupying lesions were compared. Results The median HPI of primary hepatic carcinoma was significantly higher than that of metastases. The HPI≥0.7was selected as the diadynamic criteria for different hepatic carcinoma, from metastases. The sensitive, specificity and the accuracy were high. Conclusion HPI determined using dynamic contrast-enhanced（DCE） MR imaging is useful for characterize and differential diagnosis hepatic occupying lesion.