MRI用于肝多房棘球蚴病铁沉积评估的初步研究

目的　探索MRI联合血清铁蛋白用于肝多房棘球蚴病患者肝脏铁沉积评估的效果。方法　对96例肝多房棘球蚴病确诊患者和30例健康志愿者行常规1.5T 磁共振扫描，并采集相关实验室检查资料，分析肝脏/肌肉信号强度比、血清铁蛋白水平、肝功能指标及其相关性等。结果　肝多房棘球蚴病患者与健康志愿者肝脏/肌肉信号强度比分别为（1.95 ± 0.57）和（2.22 ± 0.28），差异有统计学意义（t = 2.022，P < 0.05），且肝多房棘球蚴病患者肝脏/肌肉信号强度比与血清铁蛋白水平呈中度负相关( rs = –0.446，P < 0.01)。 结论　肝多房棘球蚴病患者肝脏内多存在异常铁沉积，而血清铁蛋白检测可辅助判断肝多房棘球蚴病患者肝脏内异常铁沉积。MRI测量的肝脏/肌肉信号强度比可作为无创性评估肝多房棘球蚴病患者肝脏铁沉积的一种方法。

Value of magnetic resonance imaging in assessment of iron deposition among patients with hepatic alveolar echinococcosis: a preliminary evaluation

Objective To assess the value of MRI combined with serum ferritin analysis in measurement of hepatic iron deposition among patients with hepatic alveolar echinococcosis.Methods A total of 96 patients with definitive diagnosis of hepatic alveolar echinococcosis and 30 healthy volunteers were enrolled and underwent routine 1.5 T MR scanning,and all laboratory examination data were captured.The liver-to-muscle signal intensity ratio,serum ferritin level and liver functions were analyzed.Results The liver-to-muscle signal intensity ratio was(1.95±0.57)in patients with hepatic alveolar echinococcosis and(2.22±0.28)in healthy volunteers(t=2.022,P<0.05),and the liver-to-muscle signal intensity ratio was negatively associated the serum ferritin level in patients with hepatic alveolar echinococcosis(rs=–0.446,P<0.01).Conclusions Abnormal iron deposition is detected in the liver of patients with hepatic alveolar echinococcosis,and serum ferritin level may be helpful for the identification of abnormal iron deposition in the liver of patients with hepatic alveolar echinococcosis.The liver-to-muscle signal intensity ratio measured by MRI may be a non-invasive approached used to assess the hepatic iron deposition in patients with hepatic alveolar echinococcosis.