慢性肝病患者血清HA、LN、Ⅳ-C、PCⅢ水平与临床分型及病理分期的关系

目的 :分析慢性肝病患者血清HA、LN、Ⅳ C、PCⅢ水平与临床分型及病理分期的关系。方法 :对 2 0 0例慢性肝病患者 (其中 98例采用肝活检确诊 )分别采用放免法测定血清HA、LN、Ⅳ C、PCⅢ水平。结果 :血清HA、LN、Ⅳ C、PCⅢ水平在慢性肝炎中度和病理S3期时开始明显高于对照组 (P <0 .0 5 ) ,但PCⅢ水平在病理S2 期就开始明显高于对照组 (P <0 .0 5 ) ,且随着肝脏炎症和纤维化程度的加重而升高。结论血清HA、LN、Ⅳ C、PCⅢ水平可反映肝纤维化程度 ,而且受肝脏炎症程度的影响。PCⅢ似是判断早期肝硬化的相对灵敏和可靠指标。

The Relationship Between the Serum Levels of HA

Purpose: Our purpose is to analyse the relationship between the serum levels of HA、 IN、 Ⅳ-C、 PC Ⅲ and different clinical type or patholgical stages in people who suffer from hepatic disease. Methods: 200 patiens which hepatic disease including 98 cases biopsied were measured the serum level of HA、 LN、 Ⅳ-C、 PCⅢ by radio-immunity method. Results: The serum levels of HA、 LN、 Ⅳ-C in patients which chronic hepatitis were significantly higher in moderate grade and pathological S3 than those of the control group (P＜0.05). The levels of PCⅢ have gone up in pathological S2 which are increased with the development of hepatic infla mmationand fibrosis. Conclusion: The serum levels of HA、 LN、 IC-C、 PCⅢ in patients could reflect the serious of hepatic fibrosis and are influenced by hepatic inflammation. PC Ⅲ might be a sensitive and reliable index for diagnosis of hepatic cirrhosis in early stage.