|
|||||
|
|
| 苯并[d]噻唑啉-2-酮-6-甲酸的合成研究 | |
| 引用本文： | 祝辉,罗自力,杨日芳,恽榴红. 苯并[d]噻唑啉-2-酮-6-甲酸的合成研究[J]. 解放军药学学报, 2011, 27(3): 197-198. DOI: 10.3969/j.issn.1008-9926.2011.03.03 |
| 作者姓名： | 祝辉 罗自力 杨日芳 恽榴红 |
| 作者单位： | 1. 成都军区联勤部药品仪器检验所,四川成都,610017 2. 军事医学科学院毒物药物研究所,北京,100850 |
| 摘 要： | 目的 设计一条简便、高效的合成路线用于苯并[d]噻唑啉-2-酮-6-甲酸的合成.方法 对氨基苯甲腈经硫氰化、关环、水解制得4-氨基-3-巯基-苯甲酸,再与氯甲酸乙酯环合反应得到苯并[d]噻唑啉-2-酮-6-甲酸.结果 目标化合物经1H-NMR和MS确证,新设计路线的总收率约62.2%.结论 本研究采用价廉易得的对氨基苯... |
| 关 键 词： | 苯并[d]噻唑啉-2-酮-6-甲酸 多巴胺D3受体 合成 |
A Study of the Synthesis of Benzo[d] Thiazolone-6-carboxylic Acid |
|
| ZHU Hui,LUO Zi-li,YANG Ri-fang,YUN Liu-hong. A Study of the Synthesis of Benzo[d] Thiazolone-6-carboxylic Acid[J]. Pharmaceutical Journal of Chinese People's Liberation Army, 2011, 27(3): 197-198. DOI: 10.3969/j.issn.1008-9926.2011.03.03 | |
| Authors: | ZHU Hui LUO Zi-li YANG Ri-fang YUN Liu-hong |
| Affiliation: | ②①Chengdu Military Institute for Drug Control,Chengdu610017,China;②Department of Medicinal Chemistry,Beijing Institute of Pharmacology and Toxicology,Beijing100850,China |
| Abstract: | Objective To design a simple and efficient synthetic method for benzo[d]thiazolone-6-carboxylic acid.Methods Benzo[d]thiazolone-6-carboxylic acid was prepared form 4-aminobenzonitrile through thiocyanation and hydrolysis to yield 4-amino-3-mercaptobenzoic acid,which was subjected to cyclization with an ethyl chlorocarbonate.Results The structure of benzo[d]thiazolone-6-carboxylic acid was identified by 1H-NMR and MS.The overall yield of the new method was 62.2%.Conclusion An efficient and high yielding proc... |
| Keywords: | benzo[d]thiazolone-6-carboxylic acid dopamine D3 receptor synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |