| 吴茱萸炮制前后挥发油成分及毒性的比较研究 |
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| 引用本文： | 张晓凤,高南南,刘红玉,杜红,杨蕾,李飞. 吴茱萸炮制前后挥发油成分及毒性的比较研究[J]. 解放军药学学报, 2011, 27(3): 229-232. DOI: 10.3969/j.issn.1008-9926.2011.03.014 |
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| 作者姓名： | 张晓凤 高南南 刘红玉 杜红 杨蕾 李飞 |
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| 作者单位： | 1. 北京中医药大学,北京,100102
2. 中国医学科学院药用植物研究所,北京,100193 |
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| 基金项目： | 国家973计划中医基础理论专项,确有疗效的有毒中药科学应用关键问题的基础研究,No.2009CB522800;有毒中药炮制减毒原理和方法学研究,No.2009CB522805 |
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| 摘 要： | 目的 分析吴茱萸炮制前后挥发油含量、组分及毒性的变化,为阐明吴茱萸炮制减毒机理提供科学依据.方法 采用水蒸气蒸馏法提取吴茱萸生品和制品挥发油,用GC-MS法鉴定化学成分.采用经典小鼠急性毒性试验,对吴茱萸生、制品挥发油毒性进行比较,并用Bliss法计算LD50值.结果 吴茱萸生、制品挥发油收率分别为0.75%和0.65...
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| 关 键 词： | 吴茱萸 炮制 挥发油 GC-MS 急性毒性 |
A Study on the Composition and Toxicity Changes of Essential Oil of Evodia rutaecarpa (Juss.) Benth.Before and After Processing |
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| ZHANG Xiao-feng,GAO Nan-nan,LIU Hong-yu,DU Hong,YANG Lei,LI Fei. A Study on the Composition and Toxicity Changes of Essential Oil of Evodia rutaecarpa (Juss.) Benth.Before and After Processing[J]. Pharmaceutical Journal of Chinese People's Liberation Army, 2011, 27(3): 229-232. DOI: 10.3969/j.issn.1008-9926.2011.03.014 |
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| Authors: | ZHANG Xiao-feng GAO Nan-nan LIU Hong-yu DU Hong YANG Lei LI Fei |
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| Affiliation: | ①①Beijing University of Chinese Medicine,Beijing100102,China;②Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences,Beijing100193,China |
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| Abstract: | Objective To analyze the composition and toxicity changes of the essential oil of Evodia rutaecarpa(Juss.) Benth.to help improve the principle of the processing method.Methods The essential oil was extracted by water-steam distillation and identified by GC-MS.The acute toxicity of essential oil of crude and processed Evodia was compared on mice in accordance with classical test methods for acute toxicity,and experimental data were calculated with Bliss method.Results The content of oil in crude and processe... |
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| Keywords: | Evodia rutaecarpa(Juss.) Benth. process essential oil GC-MS acute toxicity |
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