| 羟丙甲纤维素性质对布洛芬-羟丙甲纤维素凝胶骨架片释放度的影响 |
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| 引用本文： | 陆锦芳,戴叶军,周洁,柳淑玉,李晓曼.羟丙甲纤维素性质对布洛芬-羟丙甲纤维素凝胶骨架片释放度的影响[J].复旦学报(医学版),1996(5). |
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| 作者姓名： | 陆锦芳 戴叶军 周洁 柳淑玉 李晓曼 |
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| 作者单位： | 上海医科大学药学院药剂学教研室!200032(陆锦芳，戴叶军)，上海医科大学肿瘤医院药剂科!200032(周洁)，山东省龙口市人民医院!(266000)(柳淑玉)，卡乐康中国代表处!200031(李晓曼) |
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| 摘 要： | 研究羟丙甲纤维素（ＨＰＭ）理化性质对布洛芬－ＨＰＭＣ凝胶骨架片释放度的影响。用转篮法测定布洛芬的释放度。结果：药物的体外释放符合Ｈｉｇｕｃｈｉ方程。药物的释放度与ＨＰＭＣ的粘度、粒度以及用量有关：ＨＰＭＣ粘度越大、粒度越小，药物的释放度越慢；药物与ＨＰＭＣ的比例对药物的释放度有明显影响。结论：药物从骨架片中的释放度与ＨＰＭＣ的理性质有关。
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| 关 键 词： | 布洛芬 羟丙甲纤维素 释放度 |
EFFECT OF PHYSICOCHEMICAL PROPERTIES OF HYDROXYPROPYL METHYLCELLULOSE ON DISSOLUTION RATE OF IBUPROFEN-HYDROXYPROPYL METHYLCELLULOSE MATRIX TABLETS |
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| Lu Jinfang,Dai Yiejun,Zhou Jie,Liu Shuyu,Li Xiaoman.EFFECT OF PHYSICOCHEMICAL PROPERTIES OF HYDROXYPROPYL METHYLCELLULOSE ON DISSOLUTION RATE OF IBUPROFEN-HYDROXYPROPYL METHYLCELLULOSE MATRIX TABLETS[J].Fudan University Journal of Medical Sciences,1996(5). |
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| Authors: | Lu Jinfang Dai Yiejun Zhou Jie Liu Shuyu Li Xiaoman |
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| Abstract: | PURPOSE To study the effect of physicochemical properties of hydroxypropyl methylcellulose (HPMC) on dissolution rate of ibuprofen-HPMC matrix tablets. METHODS Dissolution rate of ibuprofen from the matrix tablets was determined by rotary basket methed. RESULTS It was found that the dissolution rate of ibuprofen-HPMC matrix tablets conformed to Higuchi equation. Higher viscosity and smaller particle size of HPMC gave slower drug release. Variation in drug/ HPMC proportion showed significant difference in dissolution rate of ibuprofen. CONCLUSIONS The dissolution rate of drug from matrix was dependent on the physicochemical properties of HPMC. |
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| Keywords: | ibuprofen hydroxypropyl methylcellulose dissolution rate |
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