中药肾病合剂减少儿童单纯型肾病综合征复发的临床研究

目的：观察中药肾病合剂对儿童单纯型肾病综合征复发的影响。方法：以肾病合剂配合强的松治疗儿童单纯型肾病综合征68例（中西药组），并随机设立强的松组33例（西药组），进行对照研究。结果：1年复发率中西药组为14.3%，对照组为59.3%，中西药组明显低于对照组（P＜0.01)。患儿治疗前血清皮质醇、IgG、IgA及CD3、CD4、CD4／CD8、红细胞C3b受体花环率均明显低于健康组（P＜0.01或P＜0.05)；中西药组患儿治疗6个月后，上述指标均明显上升，与健康组比较差异无显著性。结论：肾病合剂可减少肾病复发，其作用机制与其调整T细胞功能紊乱，改善体液免疫和红细胞免疫功能及促进肾上腺皮质功能恢复等多种途径有关。

Clinical Study on Effect of Shenbing Mixture in Reducing Recurrence of Simple Nephrotic Syndrome of Children

Objective: To observe the effect of Shenbing Mixture (SBM) of the recurrence of simple nephrotic syndrome of children. Methods: Sixty eight patients treated with SBM combined with prednisone were observed and compared with that in the control group treated with prednisone only. Results: The 1 year recurrence rate of the treated group was 14.3%, which was obviously lower than that in the control group (P<0 01). Serum level of cortisol, IgG, IgA, CD 3, CD 4, CD 4/CD 8 ratio and rosette formation rate of RBC C 3b in patients before treatment were all significantly lower than normal range. After being treated with SBM combined with prednisone, the above mentioned indexes were all improved significantly and close to normal. Conclusion: SBM had obvious effect in reducing recurrence of nephrotic syndrome in children, the mechanism is closely related to multiple pathways, including adjustment of T lymphocyte dysfunction, improving humoral immunity and RBC immune function, and promoting the recovery of adrenal cortex function.