| 血管内皮生长因子在先天性心脏病肺动脉高压中的表达及意义 |
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| 引用本文： | 张园海,项如莲,褚茂平,陆文文,吴蓉洲,陈其. 血管内皮生长因子在先天性心脏病肺动脉高压中的表达及意义[J]. 温州医学院学报, 2004, 34(2): 106-107,110 |
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| 作者姓名： | 张园海 项如莲 褚茂平 陆文文 吴蓉洲 陈其 |
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| 作者单位： | 温州医学院附属育英儿童医院,心血管内科,浙江,温州,325027 |
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| 摘 要： | ![]()
目的:探讨血管内皮生长因子(VEGF)在先天性心脏病(CHD)肺动脉高压形成和发展中的意义.方法:采用ELISA方法检测并比较50例CHD患儿[其中无肺动脉高压组(肺动脉收缩压＜30mmHg)15例,轻度肺动脉高压组(肺动脉收缩压30～49mmHg)19例,中重度肺动脉高压组(肺动脉收缩压＞50mmHg)16例]和18例健康患儿的血清VEGF.结果:轻度肺动脉高压组VEGF[(104.54±30.55)pg/ml]明显高于无肺动脉高压组[(28.23±13.47)pg/ml];中重度肺动脉高压组[(189.24±43.89)pg/ml]明显高于轻度肺动脉高压组[(104.54±30.55)pg/ml];无肺动脉高压组[(28.23±13.47)pg/ml]与正常对照组[(25.56±10.67)pg/ml]相比,差异无显著性(P＞0.05).血清ⅥGFF浓度与肺动脉收缩压呈正相关(r=0.783).结论:ⅦGF在CHD肺动脉高压血管重建中起重要作用,CHD肺动脉高压患儿血清ⅦGF浓度升高,提示VEGF与肺动脉高压的病理生理有关.
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| 关 键 词： | 先天性心脏病 肺动脉高压 血管内皮生长因子 |
| 文章编号： | 1000-2138(2004)02-0106-03 |
Expression and clinical significance of vascular endothelial growth factor in congenital heart disease with pulmonary hypertension |
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| ZHANG Yuan-hai,XIANG Ru-lian,CHU Mao-ping,et al.. Expression and clinical significance of vascular endothelial growth factor in congenital heart disease with pulmonary hypertension[J]. Journal of Wenzhou Medical College, 2004, 34(2): 106-107,110 |
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| Authors: | ZHANG Yuan-hai XIANG Ru-lian CHU Mao-ping et al. |
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| Affiliation: | ZHANG Yuan-hai,XIANG Ru-lian,CHU Mao-ping,et al.Department of Cardiology,Yuying Children's Hospital Affiliated to Wenzhou Medical College,Wenzhou 325027 |
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| Abstract: | ![]()
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| Keywords: | congenital heart disease pulmonary hypertension vascular endothelial growth factor |
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