| 甘糖酯对家兔全脑缺血再灌损伤的保护作用 |
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| 引用本文： | 张岫美,孙晓红.甘糖酯对家兔全脑缺血再灌损伤的保护作用[J].中国海洋药物,1998,17(4):15-17. |
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| 作者姓名： | 张岫美 孙晓红 |
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| 作者单位： | [1]山东医科大学基础医学院药理学教研室 [2]解放军四六四医院 |
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| 基金项目： | 山东省自然科学基金 Y95C1133 |
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| 摘 要： | 甘糖酯是一种新型的低分子量、低抗凝活性的多糖类海洋药物。本文报道甘糖酯对４动脉阻断家兔全脑缺血再灌损伤脑组织过氧化脂质（ＭＤＡ）、超氧化物歧化酶（ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）、一氧化氮（ＮＯ）和脑含水量的影响。结果显示，甘糖酯可降低全脑缺血再灌损伤的ＭＤＡ含量，提高ＳＯＤ和ＧＳＨ－Ｐｘ活性，降低脑含水量，对ＮＯ无明显影响，提示甘糖酯对全脑再灌损伤有明显的抗氧化作用。
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| 关 键 词： | 甘糖酯 脑缺血 再灌注损伤 药物疗法 脑保护作用 |
PROTECTIVE EFFECTS OF PROPYLENE GLYCOL MANNATE SULFATE ON THE WHOLE CEREBRAL LSCHEMIA/REPERFU-SION INJURY IN RABBITS |
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| Zhang Xiumei,Wei Xinbing,Sun Xiaohong,et al.PROTECTIVE EFFECTS OF PROPYLENE GLYCOL MANNATE SULFATE ON THE WHOLE CEREBRAL LSCHEMIA/REPERFU-SION INJURY IN RABBITS[J].Chinese Journal of Marine Drugs,1998,17(4):15-17. |
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| Authors: | Zhang Xiumei Wei Xinbing Sun Xiaohong |
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| Abstract: | The effects of propylene glycol mannate sulfate (PGMS) on the lipid peroxide (MDA) , superoxide dismutase (SOD) , glutathion peroxidase (GSH-Px), nitric oxide (NO)and water content in the whole cerebral ischemia/reperfusion injury rabbits induced by four-vessel occlusion,The results show that PGMS can decrease the brain water and MDA, and can increase the SOD and GSH-Px level. No significant effect on the NO level has been detected. The results suggest that the protective effects of PGMS on ischemia/reperfusion injury may be related to its antioxidation. |
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| Keywords: | propylene glycol mannate sulfate whole cerebral ischemia/reperfusioninjury malondehyde(MDA) superoxide dismutase(SOD) glutathione peroxidase(GSH-Px) brain water content nitric oxide (NO) |
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