Mechanistic study of signalling pathways in intestinal B lymphocytes using eicosapentaenoic and docosahexaenoic acid in broiler chickens |
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| Authors: | Xin Yang Yibing Wang Junhu Yao |
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| Affiliation: | 1. College of Animal Science &2. Technology, Northwest A&3. F University, Yang Ling, Shaan'xi, People's Republic of China |
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| Abstract: | The present study was conducted to investigate the effects of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and a combination of both at a ratio of 2:1 on the signalling pathways in lipopolysaccharide (LPS)-stimulated intestinal B lymphocytes from broiler chickens. The results showed that these treatments reduced the production of prostaglandin E2 (PGE2), cyclooxygenase 2 (COX-2), and phospholipase C (PLC) and increased the concentration of inositol triphosphate (IP3) significantly compared with the control group (P?2, COX-2, and PLC and increased the concentration of IP3 (P?
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| Keywords: | eicosapentaenoic acid docosahexaenoic acid signalling pathways B lymphocytes broiler chickens |
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