金威消石颗粒对大鼠肝肾及凝血功能影响的实验研究

目的：探讨金威消石颗粒对大鼠肝肾及凝血功能的影响。方法：健康SD大鼠40只，雌雄各半，随机分为金威消石颗粒高、中、低剂量组及空白对照组，分别经胃灌注不同浓度的金威消石颗粒混悬液和蒸馏水，12．5mL／kg，每天2次，每周给药6天，连续3月。然后经腹腔动脉取组1mL，检查肝肾功能和凝血酶原时间（PT）。结果：与空白对照组比较，金威消石颗粒低剂量组大鼠血浆白蛋白降低（P〈0．05），中剂量组碱性磷酸酶增高（P〈0．05），但均在正常范围内，无明显生物学意义。各剂量组大鼠血浆转氨酶、肾功能及PT与空白对照组比较，差异无显著性意义（P〉0．05）。结论：金威消石颗粒给药3月对大鼠肝肾及凝血功能未产生明显不良反应。

Effect of Jinwei Xiaoshi Granule on Hepatorenal Function and Coagulation Function in Rats

Objective:To study the impact of Jinwei Xiaoshi Granule(JXG) on hepatorenal function and coagulation function in rats.Methods:Forty healthy SD rats,half in male,were randomly divided into high-,middle-and low-dose JXG groups(in the dosages of 40.0,27.0 and 13.0g/L respectively) and blank control group.JXG and distilled water at 12.5mL/kg were given to the rats by gastric infusion,respectively,twice daily,6 days per week,and the treatment lasted 3 months.At the end of the experiment,one mililiter of blood was taken from rat celiac artery for measurement of hepatorenal function and prothrom-bin time.Results:As compared with blank control group,blood albumin level was lower(P < 0.05) in low-dosage group,and alkaline phosphatase level was higher(P < 0.05) in middle-dosage group,whereas all of them were within normal ranges.There was no significant difference in plasma aminotransferase,renal function and prothrombin time between three JXG groups and blank control group(P > 0.05).Conclusion:JXG exhibits no obvious adverse reaction on hepatorenal function and coagula-tion function in rats after 3 months’ medication.