急性有机磷农药中毒患者心肌酶活力的变化及临床意义

目的 观察急性有机磷农药中毒患者血清中天氡氨酸转氨酶（AST）、肌酸激酶（CK）和乳酸脱氢酶（LDH）的活性变化。方法 在患者入院第1日采静脉血3ml，离心后取血清进行AST、CK和LDH活性测定，测定方法均为动力学法。健康对照者在门诊采静脉血3ml，测定方法同上。结果 急性有机磷农药中毒组与健康对照组比较，血清中AST、CK和LDH活力均显著升高，而且与中毒程度有关，中毒越重，酶活性越高，EKG异常变化越显著。结论 急性有机磷农药中毒常造成心肌损伤，及时检测中毒患者血清中AST、CK和LDH活性，对了解心脏损害及其损害程度指导治疗有一定帮助。

The activity changes of myocardial enzymes of the patients with acute organophosphorus intoxication and their clinical meanings

Objective To observe the activity changes of serum aspartate aminotransferase (AST), creatine kinase (CK) and lactate dehydrogenase (LDH) of the patients with acute organic phosphorus intoxication. Methods Activities of serum AST, CK and LDH were tested with kinetics on both patients and healthy controls.Results Compared with the control, the activities of serum AST, CK and LDH in acute organophosphorus intoxicated patients were increased significantly, and related with the degree of intoxication. The more severe the intoxication was, the higher the enzyme activities were, and the more significant the abnormal change of EKG was.Conclusion Acute organophosphorus intoxication frequently caused myocardial damage.It is helpful for us to evaluate the myocardial damage and its degree by testing the activities of serum AST, CK and LDH.