Salivary and serum inflammatory mediators among pre-conception women with periodontal disease |
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Authors: | Email author" target="_blank">Hong?JiangEmail author Yiming?Zhang Xu?Xiong Emily?W?Harville Karmin?O Xu?Qian |
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Institution: | 1.School of Public Health, Fudan University,Shanghai,China;2.Clinical laboratory, Maternal and Child Health Care Hospital, Changzhou Municipality,Changzhou,China;3.Key Laboratory of Public Health Safety (Ministry of Education),Fudan University,Shanghai,China;4.Department of Epidemiology,School of Public Health and Tropical Medicine, Tulane University,New Orleans,USA;5.Department of Physiology and Pathophysiology,Faculty of Medicine,Matinoba,Canada;6.Department of Animal Science,Faculty of Agricultural & Food Sciences, University of Manitoba,Manitoba,Canada;7.St. Boniface Hospital Research Centre,Winnipeg,Canada;8.Global Health Institute, Fudan University,Shanghai,China |
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Abstract: | BackgroundThere have been inconsistent conclusions regarding the levels of inflammatory mediators in saliva and serum among people with or without periodontal disease. Although pre-conception has been put forward as the optimal time for the periodontal treatment in order to improving pregnancy outcomes, few studies have been conducted to examine inflammatory mediators in saliva and serum among pre-conception women.MethodsPre-conception women were recruited between January 2012 and December 2014. Women were provided with an oral health examination to detect periodontal disease. Salivary and serum samples were collected at the same of examination. Inflammatory mediators includinginterleukin-1 beta (IL-1β), IL-6, tumor necrosis factor alpha (TNF-α) and beta-glucuronidase (β–glucuronidase) were tested and analyzed among women with overall periodontal disease (n?=?442) or moderate/severe periodontal disease (n?=?247). Results were compared to that in women with a healthy periodontium (n?=?91).ResultsSignificantly increased concentrations of inflammatory mediators of IL-1β, IL-6, TNF-α and β-glucuronidase in saliva and IL-1β, β-glucuronidase and TNF-α in serum were found among pre-conception women with moderate/severe periodontal disease, compared with women without periodontal disease. Significantly increased levels were also found in all the above saliva inflammatory mediators and in serum IL-1β and TNF-α among women with overall periodontal disease. The levels of all inflammatory mediators in saliva and almost all inflammatory mediators except IL-6 in serum significantly increased with severity of periodontal disease.ConclusionPeriodontal disease is highly associated with the elevated levels of inflammatory mediators in saliva and some mediators in serum among pre-conception women. |
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