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Exosome swarms eliminate airway pathogens and provide passive epithelial immunoprotection through nitric oxide |
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| Authors: | Angela L. Nocera Sarina K. Mueller Jules R. Stephan Loretta Hing Philip Seifert Xue Han Derrick T. Lin Mansoor M. Amiji Towia Libermann Benjamin S. Bleier |
| Affiliation: | 1. Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Mass;5. Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Mass;2. Department of Otolaryngology/Head and Neck Surgery, University of Erlangen-Nuremberg, Erlangen, Germany;3. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Mass;4. Department of Biomedical Engineering, Boston University, Boston, Mass;6. Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, Mass;7. BIDMC Genomics, Proteomics, Bioinformatics and Systems Biology Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass |
| Abstract: |  |
| Keywords: | Exosome innate immunity CD81 epithelium sinonasal mucus nitric oxide proteomics AMP Antimicrobial peptide BEGM Bronchial epithelial growth medium CTCF Corrected total cell fluorescence HSNECC Human sinonasal epithelial cell culture IKK2 Inhibitor of nuclear factor κB kinase MCC Mucociliary clearance NMDE Nasal mucosa–derived exosome NO Nitric oxide NOS2 nitric oxide synthase PAMP Pathogen-associated molecular pattern PRR Pattern recognition receptor PVA Polyvinyl alcohol TLR Toll-like receptor TSB Tryptic soy broth UCF Ultracentrifugation |
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