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Reconstruction of LPS Transfer Cascade Reveals Structural Determinants within LBP,CD14, and TLR4-MD2 for Efficient LPS Recognition and Transfer
Authors:Je-Kyung Ryu  Soo Jin Kim  Sang-Hyun Rah  Ji In Kang  Hi Eun Jung  Dongsun Lee  Heung Kyu Lee  Jie-Oh Lee  Beom Seok Park  Tae-Young Yoon  Ho Min Kim
Affiliation:1. National Creative Research Initiative Center for Single-Molecule Systems Biology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea;2. Department of Physics, KAIST, Daejeon 34141, Korea;3. Biomedical Science and Engineering Interdisciplinary Program, KAIST, Daejeon 34141, Korea;4. Graduate School of Medical Science & Engineering, KAIST, Daejeon 34141, Korea;5. Department of Chemistry, KAIST, Daejeon 34141, Korea;6. Department of Biomedical Laboratory Science, College of Health Science, Eulji University, Seongnam 461-713, Korea;7. Center for Nanomedicine, Institute for Basic Science (IBS), Yonsei University, Seoul 03722, Korea;8. Yonsei-IBS Institute, Yonsei University, Seoul 03722, Korea
Abstract:
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  • Keywords:innate immunity  LPS recognition  LPS transfer  LBP  CD14  TLR4/MD2  single-molecule fluorescence analysis  negative-stain EM
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