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The Delayed Effect of Sodium Valproate on the Photoconvulsive Response in Man |
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| Authors: | A. J. Rowan CD. Binnie C. A. Warfield H. Meinardi J. W. A. Meijer |
| Affiliation: | Instituut voor Epilepsiebestrijding, Heemstede, The Netherlands |
| Abstract: | The acute effect of a single oral dose of sodium valproate on the photoconvulsive response has been studied. In 7 of 9 patients naive to this drug photosensitivity was abolished or reduced. A similar effect was seen in only 2 of 7 already receiving chronic sodium valproate therapy. The effect appeared 1 to 5 hr (mean, 3 hr) after attainment of peak sodium valproate concentration and lasted up to 5 days. |
| Keywords: | EEG Intermittent photic stimulation Photoconvulsive response Sodium valproate Anti-epileptic drugs |