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Respiratory Complications Lead to the Diagnosis of Chronic Granulomatous Disease in Two Adult Patients
Authors:Sylvie Colin de Verdière  Esther Noel  Claire Lozano  Emilie Catherinot  Mickael Martin  Elisabeth Rivaud  Louis-Jean Couderc  Hélène Salvator  Jacinta Bustamante
Affiliation:1.Respiratory Diseases Department,Foch Hospital,Suresnes,France;2.Internal Medicine Department,Strasbourg University Hospital,Strasbourg,France;3.Center for the Study of Primary Immunodeficiencies,Necker Hospital for Sick Children,Paris,France;4.Clinical Immunology and Internal Medicine, Center for Rare Autoimmune Diseases,Strasbourg University Hospital, CNRS 3572,Strasbourg,France;5.Simone Veil Medical School of Versailles-Saint Quentin-en-Yvelines University, UPRES EA 220,Versailles,France;6.Laboratory of Human Genetics of Infectious Diseases, Necker Branch,Institut National de la Santé et de la Recherche Médicale, INSERM-U1163,Paris,France;7.Imagine Institute,Paris Descartes University,Paris,France;8.St. Giles Laboratory of Human Genetics of Infectious Diseases Rockefeller Branch,Rockefeller University,New York,USA
Abstract:
Chronic granulomatous disease (CGD) is a primary immunodeficiency associated to multiple life-threatening bacterial and fungal infections, beginning in childhood. There are rare cases of diagnosis in adulthood. We describe here two cases of late diagnosis in adults: a 45-year-old woman and 59-year-old-man. CGD diagnosis should be considered in adult patients with unexplained infectious diseases with tissue granuloma.
Keywords:
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