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| 6-羧基壳聚糖的制备及血液相容性研究 | |
| 引用本文： | 杨越冬,于九皋,周永国,啜惠民,王东妮. 6-羧基壳聚糖的制备及血液相容性研究[J]. 中国生物医学工程学报, 2007, 26(4): 605-609 |
| 作者姓名： | 杨越冬 于九皋 周永国 啜惠民 王东妮 |
| 作者单位： | 1. 天津大学理学院化学系,天津,300072;河北科技师范学院化学系,秦皇岛,066004 2. 天津大学理学院化学系,天津,300072 3. 河北科技师范学院化学系,秦皇岛,066004 4. 青岛市第三人民医院检验科,青岛,266041 |
| 基金项目： | 河北省自然科学基金;河北省教育厅科研项目 |
| 摘 要： | 将壳聚糖溶于0.5mol/L的乙酸,再以NO2选择性氧化壳聚糖分子中氨基葡萄糖单元的6位羟甲基成羧基,制备了6-羧基壳聚糖.红外光谱分析表明该反应选择性较高,产物保持了壳聚糖基本的链结构;扫描电镜和DSC分析发现,6-羧基壳聚糖与壳聚糖的微纤结构不同,其分子构象卷曲,热稳定性较壳聚糖差.抗凝血测试、溶血测试及扫描电镜观察表明：与壳聚糖相比,6-羧基壳聚糖抗凝血性能大大提高,溶血率明显降低,6-羧基壳聚糖具有很好的血液相容性,其血液相容性随壳聚糖氧化度的提高而提高. |
| 关 键 词： | 壳聚糖 6-羧基壳聚糖 血液相容性 二氧化氮 |
| 文章编号： | 0258-8021（2007）04-0605-05 |
| 修稿时间： | 2006-03-142007-01-08 |
Preparation and Blood Compatibility of 6-Carboxy Chitosan |
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| YANG Yue-Dong,YU Jiu-Gao,ZHOU Yong-Guo,CHUO Hui-Min,WANG Dong-Ni. Preparation and Blood Compatibility of 6-Carboxy Chitosan[J]. Chinese Journal of Biomedical Engineering, 2007, 26(4): 605-609 | |
| Authors: | YANG Yue-Dong YU Jiu-Gao ZHOU Yong-Guo CHUO Hui-Min WANG Dong-Ni |
| Abstract: | The hydroxymethyl groups of 2-amino-2-deoxy-D-glucose units in chitosan were selectively oxidized to carboxyl groups with NO2 gas to form 6-carboxy-chitosan in aqueous 0.5mol/L acetic acid and confirmed by FTIR spectra. SEM study and DSC analysis showed that it is spherulite in 6-carboxy-chitosan rather than micro-fiber structure as in chitosan. Antithrombosis test, hemolysis test, and blood cell morphology observation with SEM revealed that 6-carboxy chitosan had superior blood compatibility to chitosan. The blood compatibility of 6-carboxy chitosan was improved with the degree of oxidization increased. |
| Keywords: | chitosan 6-carboxy chitosan blood compatibility NO2 |
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