超氧化物歧化酶对实验性骨折愈合的影响

目的：探讨超氧化物歧化酶（ＳＯＤ）对实验性骨折愈合的作用。方法：应用３Ｈ－脯氨酸和４５Ｃａ－氯化钙无载体放射性核素体内示踪法，检测了ＳＯＤ对实验性骨折过程中基质形成与钙化的影响，并观察了骨痂组织细胞的形态学变化。结果：ＳＯＤ使３Ｈ－脯氨酸和４５Ｃａ－氯化钙参入早期骨痂的量增加（与对照组相比，Ｐ＜０．０１），４５Ｃａ／３Ｈ的比率提高迅速。早期骨痂内毛细血管含量增加；软骨细胞、成纤维细胞功能活跃，基质钙化迅速、完全，骨性骨痂发生早。结论：ＳＯＤ可作为促进骨折愈合的辅助疗法。

Effect of superoxide dismutase for experimental fracture healing

AIM: To investigate the effects of superoxide dismutase (SOD) on fracture healing. METHODS: Ralioisotop tracers techology (e.g. intraperitoneal 3H proline and 45Ca calcium chloride carrier free solution) was used to detecte the effects of SOD on formation and calcification of collagenous and electrosmicroscope used to examin the histologic and ultrastructural features of callus. RESULTS: ① The amount of 3H and 45Ca was increased, and the 45Ca/3H ratio increased more rapidly after using SOD in the calls; ② Capillary formation was abundent ,the osteoblasts and fibroblasts were more active in forming bony tissues; ③ Mineralization of collagenous matrix was accelerated and osification process was shorten during the fracture healing. CONCLUSIONS: It is suggested that the healing of experimental fracture was expedited as a result of treatment with SOD.