| 前胡丙素对肾型高血压大鼠血压及尾动脉反应性的影响 |
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| 引用本文： | 吴冬梅 李庆平. 前胡丙素对肾型高血压大鼠血压及尾动脉反应性的影响[J]. 中国药理学通报, 1997, 13(3): 242-243 |
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| 作者姓名： | 吴冬梅 李庆平 |
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| 作者单位： | 南京医科大学心血管药理研究室 |
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| 摘 要： | 目的：观察前胡丙素对肾型高血压大鼠血压及尾动脉反应性的影响。方法：两肾一夹ＳＤ大鼠，术后７ｗｋ始给予前胡丙素２０ｍｇ·ｋｇ－１·ｄ－１ｉｇ，给药第９周末测离体尾动脉反应性。结果：前胡丙素明显降低肾型高血压大鼠血压，用药９ｗｋ后血压较给药前下降４３％，较溶剂对照组下降４４％。尾动脉对ＮＥ和ＫＣｌ的反应性显著降低，量效曲线向右下移位。结论：前胡丙素的降压作用与其对血管平滑肌的松弛作用有关。
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| 关 键 词： | 前胡丙素；肾型高血压；大鼠尾动脉 |
Effects of praeruptorin C on blood pressure of renal hypertensive rats and reactivity of isolated rat tail artery |
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| WU Dong Mei,LI Qing Ping,RAO Man Ren. Effects of praeruptorin C on blood pressure of renal hypertensive rats and reactivity of isolated rat tail artery[J]. Chinese Pharmacological Bulletin, 1997, 13(3): 242-243 |
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| Authors: | WU Dong Mei LI Qing Ping RAO Man Ren |
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| Abstract: | AIM:To observe the effects of praeruptorin C(Pra C) on blood pressure and the reactivity of isolated tail artery of renal hypertensive rats. METHODS:2K 1C SD renal hypertensive rats, treated with Pra C(20 mg·kg -1 ·d -1 , ig) for 9 wk, the reaction of rat tail artery to KCl and NE were studied. RESULTS:Pra C significantly decreased the blood pressure, which was lower 43% and 44% than that before Pra C administration and solvent treated group, respectively, and inhibited the contractive reaction of rat tail artery to either KCl or NE, with both dose response curves being shifted down and right. CONCLUSIONS:The effect of Pra C on blood pressure was connected with its effects on the reactivity of rat tail artery in hypertension. |
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| Keywords: | praeruptorin C renal hypertension rat tail artery |
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