血清双酚A水平与多囊卵巢综合征相关性的初步研究

采集43例多囊卵巢综合征（PCOS）患者与37例正常女性的血清,应用酶联免疫吸附试验（ELISA）方法检测双酚A的含量.PCOS组血清双酚A的含量明显高于正常对照组,差异有统计学意义（P＜0.05）；双酚A含量与肥胖和基础黄体生成素均呈正相关（P ＜0.05）;PCOS组中高雄激素组与非高雄激素组之间,双酚A含量差异无统计学意义；胰岛素抵抗组（PCOS-IR）与非胰岛素抵抗组（PCOS-NIR）之间,双酚A含量差异无统计学意义,但PCOS-IR稍低于PCOS-NIR.双酚A在PCOS患者中含量高,其可能与PCOS的肥胖和基础黄体生成素相关.

Relevance of bisphenol A and polycystic ovary syndrome

To explore the relationship and possible mechanism of reproductive function of bisphenol A （BPA） with polycystic ovary syndrome （PCOS）.Serum specimens were collected from 43 PCOS patients and 37 healthy women.And the level of BPA was detected by enzyme-linked immunosorbent assay （ELISA）.The serum level of BPA in PCOS were significantly higher than that in the control group.And the inter-group difference was significant （P ＜ 0.05）.The patient level of BPA was positively related with obesity and basic luteinizing hormone （LH） （P ＜ 0.05）.In the PCOS group,no significant correlation existed between hyperandrogenemia and non-hyperandrogenemia （P ＞ 0.05）.Although no difference existed between insulin and non-insulin resistance,the level of BPA in insulin resistance group was lower than in non-insulin resistance group.A higher level of BPA may be associated with obesity and basic LH in PCOS.