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Vestibuloprotective activity of seal serum proteins
Authors:V. V. Yasnetsov  A. N. Gromov  N. M. Kiseleva  D. Yu. Rusakov  S. G. Batrakov  A. V. Evstratov  V. S. Shashkov
Affiliation:(1) Scientific-Industrial Center Hydrobios, Ministry of Public Health, Moscow
Abstract:Cat and rat experiments show that the protein fraction isolated from blood serum of the Greenland seal has a protective activity against motion sickness. This activity is comparable to that of the classical vestibuloprotector scopolamine and is greater than that of diprazine. Radioligand assay of the receptor binding showed that the serum protein fraction has the highest affinity for α2-adrenoceptors, μ-opioid, and benzodiazepine receptors. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol 117, N o 4, pp. 444–445, April, 1994
Keywords:serum protein fraction    motion sickness    opioid and benzodiazepam receptors
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