| 肾肝宁胶囊联合他克莫司治疗肾病综合征的临床研究 |
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| 引用本文： | 徐婧,王冰月,李春红,董昆,王洪玲,田洁.肾肝宁胶囊联合他克莫司治疗肾病综合征的临床研究[J].现代药物与临床,2019,34(12):3647-3650. |
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| 作者姓名： | 徐婧 王冰月 李春红 董昆 王洪玲 田洁 |
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| 作者单位： | 天津市第三中心医院(天津市肝胆疾病研究所,天津市人工细胞重点实验室,卫生部人工细胞工程技术研究中心) 肾内科,天津 300170 |
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| 摘 要： | 目的研究肾肝宁胶囊联合他克莫司胶囊治疗肾病综合征的临床疗效。方法选取2016年4月—2019年4月天津市第三中心医院收治的100例肾病综合征患者为研究对象,所有患者随机分为对照组和治疗组,两组各50例。对照组口服他克莫司胶囊,0.05 mg/(kg·d),使血药浓度维持在10 ng/mL;治疗组在对照组基础上口服肾肝宁胶囊,3粒/次,3次/d。两组患者持续治疗2个月。观察两组的临床疗效,比较两组的肾功能指标、血清炎性因子水平。结果治疗后,对照组和治疗组的总有效率分别为82.00%、94.00%,两组比较差异有统计学意义(P0.05)。治疗后,两组患者24 h尿蛋白、血尿素氮和血肌酐水平均显著降低,同组治疗前后比较差异有统计学意义(P0.05);并且治疗组患者24h尿蛋白、血尿素氮和血肌酐水平明显低于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)水平均显著降低,同组治疗前后比较差异有统计学意义(P0.05);并且治疗组患者TNF-α、CRP水平均明显低于对照组,两组比较差异具有统计学意义(P0.05)。结论肾肝宁胶囊联合他克莫司胶囊治疗肾病综合征具有较好的治疗效果,可改善肾功能指标,降低炎性反应,具有一定的临床推广应用价值。
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| 关 键 词： | 肾肝宁胶囊 他克莫司胶囊 肾病综合征 肾功能指标 炎性因子 |
| 收稿时间： | 2019/7/14 0:00:00 |
Clinical study on Shenganning Capsules combined with tacrolimus in treatment of nephrotic syndrome |
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| XU Jing,WANG Bing-yue,LI Chun-hong,DONG Kun,WANG Hong-ling and TIAN Jie.Clinical study on Shenganning Capsules combined with tacrolimus in treatment of nephrotic syndrome[J].Drugs & Clinic,2019,34(12):3647-3650. |
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| Authors: | XU Jing WANG Bing-yue LI Chun-hong DONG Kun WANG Hong-ling and TIAN Jie |
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| Institution: | Department of Nephrology, Tianjin Third Central Hospital(Tianjin Institute of Hepatobiliary Diseases;Tianjin Key Laboratory of Artificial Cells;Research Center of Artificial Cell Engineering Technology of Ministry of Health), Tianjin 300170, China,Department of Nephrology, Tianjin Third Central Hospital(Tianjin Institute of Hepatobiliary Diseases;Tianjin Key Laboratory of Artificial Cells;Research Center of Artificial Cell Engineering Technology of Ministry of Health), Tianjin 300170, China,Department of Nephrology, Tianjin Third Central Hospital(Tianjin Institute of Hepatobiliary Diseases;Tianjin Key Laboratory of Artificial Cells;Research Center of Artificial Cell Engineering Technology of Ministry of Health), Tianjin 300170, China,Department of Nephrology, Tianjin Third Central Hospital(Tianjin Institute of Hepatobiliary Diseases;Tianjin Key Laboratory of Artificial Cells;Research Center of Artificial Cell Engineering Technology of Ministry of Health), Tianjin 300170, China,Department of Nephrology, Tianjin Third Central Hospital(Tianjin Institute of Hepatobiliary Diseases;Tianjin Key Laboratory of Artificial Cells;Research Center of Artificial Cell Engineering Technology of Ministry of Health), Tianjin 300170, China and Department of Nephrology, Tianjin Third Central Hospital(Tianjin Institute of Hepatobiliary Diseases;Tianjin Key Laboratory of Artificial Cells;Research Center of Artificial Cell Engineering Technology of Ministry of Health), Tianjin 300170, China |
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| Abstract: | |
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| Keywords: | Shenganning Capsules Tacrolimus Capsules nephrotic syndrome renal function index inflammatory factor |
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