右美托咪定联合帕瑞昔布钠对老年结直肠癌术后疼痛的影响

目的 观察右美托咪定联合帕瑞昔布钠对老年结直肠癌术后疼痛的影响。方法 选择>60岁老年结直肠癌患者61例，按随机数表法将其分为2组，其中对照组（31例）患者均采用右美托咪定治疗，实验组（30例）患者均采用右美托咪定联合帕瑞昔布钠治疗。观察比较2种给药方案对老年结直肠癌术后疼痛的影响。结果 实验组麻醉后监测治疗室（PACU）停留时间较短；术后2，12，24 h 2组患者视觉模拟评分法（VAS）评分比较提示，随着时间推移，患者VAS评分水平逐渐减低，且实验组的VAS评分水平分别更低；同时，实验组患者自控镇痛（PCA）总次数低于对照组，且镇痛效果更佳，差异均具有统计学意义（P<0.05）。从情绪方面来看，术后患者48 h和96 h愤怒量表分数均以实验组更低；此外，实验组患者满意度、术后肠蠕动恢复时间均优于对照组，差异具有统计学意义（P<0.05）。结论 右美托咪定联合帕瑞昔布钠对老年结直肠癌术后疼痛的控制最优，值得临床推荐使用。

Effects of Dexmedetomidine Combined with Parecoxib Sodium on Postoperative Pain in Elderly Patients with Colorectal

OBJECTIVE To investigate the effect of dexmedetomidine combined with parecoxib sodium on postoperative pain in elderly patients with colorectal cancer. METHODS Sixty-one elderly patients over 60 years old with colorectal cancer were randomly divided into two groups, the control group(31 cases):patients were treated with dexmedetomidine treatment; the experimental group(30 cases):patients were treated with dexmedetomidine combined with parecoxib treatment. To observe and compare the effects of 2 medication schemes on elderly patients after colorectal cancer surgery. RESULTS The postanesthesia care unit(PACU) residence time of the experimental group was shorter than the control group. According to the patients'' visual analogue score (VAS) score after 2, 12, and 24 h, the level of VAS score in the 2 groups decreased with time, and the VAS score of the experimental group was lower. The total number of patient controlled analgesia (PCA) in the experimental group was lower than that in the control group, and the analgesic effect was better, the differences were statistically significant(P<0.05). In terms of emotion, the scores of anger scale after 48 h and 96 h were lower in the experimental group(P<0.05). In addition, compared with the the control group, patients'' satisfaction score was higher and the recovery time of postoperative intestinal peristalsis was even shorter in the experimental group, and the difference were statistically significant(P<0.05). CONCLUSION the control of deemethomidine combined with parecoxib sodium on postoperative pain in elderly patients with colorectal cancer is better, it is recommended for clinical use.