药物性肝损伤诊断治疗进展概述

摘 要药物性肝损伤（DILI）是指使用一种或多种药物后，由药物或其代谢产物引起的肝脏损伤。引起DILI最常见的药物包括：中药、抗结核药、抗肿瘤药、解热镇痛药、抗生素等，目前保健品、减肥药、食品添加剂等导致肝功能损伤越来越受到临床医生的重视。DILI可表现为急性或慢性肝损伤，可进展至肝硬化，轻者停药后肝功能可自行恢复，重者可出现黄疸、肝衰竭和各种并发症危及生命。随着生活水平的提高、生活习惯的改变及药物种类的增多，DILI的发病率逐年升高，其病因、诊断和治疗方面的相关问题越来越受到关注。本文将从DILI的诊断、治疗及预后等方面进行综述。

Diagnosis and Treatment of Drug induced Liver Injury

ABSTRACTDrug induced liver injury (DILI) is a liver injury caused by a drug or its metabolites after using one or more drugs. The common drugs that cause DILI include traditional Chinese medicine,anti tuberculosis medicine, antitumor drug, antipyretic analgesics, antibiotics and so on. At present, health care products, diet pills, food additives and other causes liver function injury is more and more attention by clinicians. DILI is characterized by acute or chronic liver damage, and for a worse situation, it can cause liver cirrhosis, patients with slight symptom can recover after stopping using the drugs. However, patients with severe symptom will suffer from icteric,liver failure, and a variety of life threatening complications. With the improvement of living standards, changes of living habits and the increase of drug types,the incidence of DILI increases year by year, and more and more attention is being paid to the related problems in etiology, diagnosis and treatment. This paper will study DILI''s diagnosis, treatment and prognosis and then make reviews to them.