血脂全套分析在肾病综合征诊断中的应用价值

目的 探讨肾病综合征（NS）患者血浆总胆固醇（CHOL）、三酰甘油（TG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、载脂蛋白A1（Apo-A1）及载脂蛋白B （Apo-B）水平变化及临床意义。方法 选择2013年1月至2016年11月太和县人民医院收治的60例NS患者为NS疾病组，同期住院其他肾脏疾病患者30例（非NS患者）为疾病对照组，50例本院健康体检者为正常对照组，检测并比较治疗前3组对象的CHOL、TG、HDL、LDL、Apo-A1及Apo-B水平。结果 NS疾病组的CHOL、TG、HDL、LDL、Apo-A1及Apo-B水平分别为（9.18±2.50） mmol/L、（3.00±1.55） mmol/L、（1.65±0.53） mmol/L、（5.83±2.27） mmol/L、（1.66±0.42） g/L、（1.83±0.61） g/L；疾病对照组CHOL、TG、HDL、LDL、Apo-A1及Apo-B水平分别为（4.22±0.98） mmol/L、（1.89±1.35） mmol/L、（1.13±0.44） mmol/L、（2.39±0.70） mmol/L、（1.06±0.32） g/L、（0.88±0.22） g/L；正常对照组CHOL、TG、HDL、LDL、Apo-A1及Apo-B的水平分别为（4.42±0.46） mmol/L、（1.10±0.31） mmol/L、（1.33±0.21） mmol/L、（2.37±0.43） mmol/L、（1.31±0.17） g/L、（0.80±0.12） g/L。3组研究对象的生化指标差异有统计学意义（P<0.05），且NS疾病组各指标水平均高于疾病对照组、正常对照组，差异有统计学意义（P<0.05），而疾病对照组与正常对照组的TG、HDL和Apo-A1水平差异有统计学意义（P<0.05）。3组研究对象的CHOL、TG、HDL、LDL、Apo-A1及Apo-B的异常率差异有统计学意义（P<0.05）。结论 与正常健康人和非NS肾病患者比较，NS患者存在明显的血脂异常。

Clinical value of complete blood lipid analysis in diagnosis of nephrotic syndrome

Objective To investigate the concentration changes and clinical significance of plasma total cholesterol (CHOL), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), apolipoprotein A1 (Apo-A1) and apolipoprotein B (Apo-B) in nephrotic syndrome (NS) patients.Methods Clinical data werecollected from January 2013 to November 2016 in Taihe People''s Hospital. The subjectincluded 60 NS patients in disease group, 30 patients with kidney disease (non-nephrotic syndrome) in disease control group, and50 healthy onesin normal control group. The levels of CHOL, TG, HDL, LDL, Apo-A1 and Apo-B in three groups were detected and compared.Results CHOL,TG,HDL,LDL, Apo-A1 and Apo-B levels in NS patients were (9.18±2.50)mmol/L,(3.00±1.55)mmol/L,(1.65±0.53)mmol/L,(5.83±2.27)mmol/L,(1.66±0.42) g/L and (1.83±0.61)g/L, respectively. CHOL,TG,HDL,LDL,Apo-A1 and Apo-B levels in disease controls were (4.22±0.98)mmol/L,(1.89±1.35)mmol/L,(1.13±0.44)mmol/L,(2.39±0.70)mmol/L,(1.06±0.32)g/L and (0.88±0.22)g/L, respectively. In healthy controls, CHOL,TG,HDL,LDL,Apo-A1 and Apo-B levels were(4.42±0.46) mmol/l,(1.10±0.31) mmol/L,(1.33±0.21)mmol/L,(2.37±0.43)mmol/L,(1.31±0.17)g/L and(0.80±0.12)g/L, respectively. The biochemical indexes of the three groups were statistically significant(P<0.05). The levels of TG,HDL and Apo-A1 between disease control group and normal control group were statistically significant(P<0.05). The abnormal rate difference of CHOL, TG, HDL,LDL, Apo-A1 and Apo-B among the three groups was statistically significant(P<0.05).Conclusion Compared with normal health people and patients with non-NS nephropathy, there is a significant increase in blood lipids in NS patients.