| 系统性红斑狼疮动物模型及其发病机制研究进展 |
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| 引用本文： | 吴岚,蔡同凯,张立超,姜远英,曹永兵.系统性红斑狼疮动物模型及其发病机制研究进展[J].药学实践杂志,2018,36(6):481-483,492. |
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| 作者姓名： | 吴岚 蔡同凯 张立超 姜远英 曹永兵 |
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| 作者单位： | 第二军医大学药学院新药研究中心, 上海 200433,第二军医大学药学院新药研究中心, 上海 200433,上海市中医医院药剂科, 上海 200071,第二军医大学药学院新药研究中心, 上海 200433,第二军医大学药学院新药研究中心, 上海 200433;上海市中西医结合医院中西医结合脉管病研究所, 上海 200082 |
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| 基金项目： | 国家"重大新药创制"科技重大专项,项目编号：2018X09201008-002-071;上海市科委科技创新行动计划,项目编号：18401932700 |
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| 摘 要： | 系统性红斑狼疮模型主要分为自发性和诱导性模型,通过查阅文献探究近年来国内外学者对自发性和诱导性红斑狼疮模型的研究,并阐明不同类型系统性红斑狼疮模型的主要特征,针对其各自优势与不足筛选更稳定、更适合自身免疫的红斑狼疮小鼠模型,为后期红斑狼疮治疗药物的研究和筛选提供合适的动物模型,有助于抗系统性红斑狼疮新药的研发。
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| 关 键 词： | 系统性红斑狼疮 小鼠 动物模型 |
| 收稿时间： | 2018/3/19 0:00:00 |
| 修稿时间： | 2018/9/12 0:00:00 |
Study on animal models and mechanisms of systemic lupus erythematosus |
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| WU Lan,CAI Tongkai,ZHANG Lichao,JIANG Yuanying and CAO Yongbing.Study on animal models and mechanisms of systemic lupus erythematosus[J].The Journal of Pharmaceutical Practice,2018,36(6):481-483,492. |
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| Authors: | WU Lan CAI Tongkai ZHANG Lichao JIANG Yuanying and CAO Yongbing |
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| Institution: | Center for New Drug Research, School of Pharmacy, Second Military Medical University, Shanghai 200433, China,Center for New Drug Research, School of Pharmacy, Second Military Medical University, Shanghai 200433, China,Department of Pharmacy, Shanghai Traditional Chinese Medicine Hospital, Shanghai 200071, China,Center for New Drug Research, School of Pharmacy, Second Military Medical University, Shanghai 200433, China and Center for New Drug Research, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;Shanghai TCM-Integrated Hospital Shanghai TCM-Integrated Research Institute of pulse tube disease, Shanghai 200082, China |
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| Abstract: | Objective Systemic lupus erythematosus (SLE) models were mainly divided into spontaneous and induced models. Through the literature,spontaneous and induced SLE models and their main characteristics were reviewed, which provided references for the researchers to choose appropriate models for studying specific pathogenic mechanism and diagnostic criteria, searching for targeted treatment interventions and developing potential therapeutic drugs. |
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| Keywords: | systemic lupus erythematosus murine animal models |
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