治疗肝纤维化药物递送系统研究进展

肝纤维化是影响人类健康的重大疾病。目前用于治疗肝纤维化的药物存在药物溶解度低、无肝脏特异性及易产生不良反应等问题。在肝纤维化治疗中，为提高药物治疗效果，大量纳米药物递送载体及靶向治疗策略被学者广泛关注。本文从载体及修饰配体类型综述了近年来应用于肝纤维化治疗的药物递送系统及其主动靶向策略，为设计安全高效的肝纤维化药物递送系统，实现肝纤维化的高效治疗提供理论参考。

Advances in drug delivery systems for the treatment of liver fibrosis

Liver fibrosis is a major disease that affects human health. Currently, drugs used for the treatment of hepatic fibrosis have such problems as low drug solubility, lack of liver specificity and possible occurrence of side-effects. In order to improve the anti-fibrosis therapeutic efficacy, various nano-drug delivery systems and targeting strategies are explored in liver fibrosis therapy. This review summarizes the drug delivery systems and targeting strategies that have been applied to liver fibrosis therapy in recent years from the types of carriers and modified ligands, which serve as a basis of designing safe and effective drug delivery systems for liver fibrosis therapy.