消囊调经汤对非肥胖型多囊卵巢综合征患者卵巢储备及卵泡发育的影响

目的:探讨消囊调经汤对非肥胖型多囊卵巢综合征（Polycystic ovary syndrome，PCOS）患者卵巢储备及卵泡发育的影响。方法:按随机数字表法将2015年2月至2017年6月河南省中医院接诊的非肥胖型PCOS患者60例分为两组。研究组30例患者接受消囊调经汤治疗，对照组30例患者接受炔雌醇环丙孕酮片治疗。连续治疗3个月后，比较两组中医症状积分、临床疗效、卵巢储备功能促黄体生成素（Leuteinizing hormone，LH）、卵泡刺激素（Follicle-stimula-tinghormone，FSH）、雌二醇（Estradiol，E2）、泌乳素（Prolactin，PRL）、睾酮 （Throttle，T）、LH/FSH]以及卵泡发育情况{卵泡数量、卵巢体积、卵泡最大直径以及卵巢周围血流参数卵巢间质的血流指数（Flow index，FI）、血管化指数（Vascularization index，VI）、血管化血流指数（Vascularization flowindex，VFI）]}。结果：研究组和对照组中医症状积分分别为（9.64±1.01）分、（15.02±1.12）分，差异具有统计学意义（P<0.05）；研究组治疗总有效率为93.33%（28/30）高于对照组的73.33%（22/30），差异具有统计学意义（P< 0.05）；对照组LH、PRL、T、LH/FSH高于研究组，FSH、E2低于研究组，差异具有统计学意义（P<0.05）；对照组卵泡数量、卵巢体积、FI、VI、VFI高于研究组，卵泡最大直径低于研究组，差异具有统计学意义（P<0.05）。结论:对非肥胖型PCOS患者实施消囊调经汤治疗效果显著，能有效减轻患者临床症状，改善卵巢储备功能，促进卵泡发育，利于卵巢排卵功能的早期恢复。

Effects of Xiaonang Tiaojing Decoction on Ovarian Reserve and Follicular Development in Non-obese Polycystic Ovary Syndrome Patients

Objective: To investigate the effect of Xiaonang Tiaojing decoction on ovarian reserve and follicular development in non-obese polycystic ovary syndrome (PCOS) patients. Methods: 60 non-obese PCOS patients in the Henan Province Hospital of TCM from February 2015 to June 2017 were divided into two groups by random number table, with 30 cases in each group. Research group was given Xiaonang Tiaojing decoction, while control group was treated with ethinylestradiol and cyproterone acetate tablets. After three- month treatment, the TCM symptom score, clinical efficacy, ovarian reserve function leuteinizing hormone (LH), follicle-stimula- tinghormone (FSH), estradiol (E2), prolactin (PRL), throttle (T), LH/FSH], follicular development {number of follicles, ovarian volume, maximum diameter of the follicle, blood flow parameters around the ovaries flow index (FI), vascularization index (VI), vascularization flow index (VFI)]} were compared between the two groups. Results: The TCM symptom scores of research group and control group were (9.64±1.01) points and (15.02±1.12) points (P<0.05); The total effective rate of research group 93.33% (28/30)] was higher than control group 73.33% (22/30)] (P<0.05); The LH, PRL, T, LH/FSH in control group were higher than those in research group, but FSH and E2 were lower than research group (P<0.05); The number of follicles, ovarian volume, FI, VI, VFI in control group were higher than those in research group, and the maximum diameter of the follicle was lower than research group (P<0.05). Conclusion: Xiaonang Tiaojing decoction in treatment of non- obese PCOS is effective. It can reduce clinical symptoms, improve ovarian reserve function, promote follicular development, facilitate early recovery of ovarian ovulation function.