钛种植体表面早期成骨方式的动物模型研究

目的：研究适合用于观察钛种植体表面早期成骨方式的动物模型。方法对原有的种植体植入模式进行改进，使种植体植入动物体内的初始状态为种植体外螺纹贴于种植窝骨壁，种植体螺纹内部与周围骨壁保持一定距离。4只Beagle犬下颌骨延期植入20枚种植体，植入后2周和4周分别处死2只Beagle犬，对标本进行组织学观察。结果4只Beagle犬手术创口均达到一期愈合，未出现种植体松动。组织学观察可见种植体表面新骨生成，种植体周围骨壁新骨生成，可清楚地观察到新骨生成方向，可观察到接触成骨和距离成骨。结论本研究创建的动物模型可以清晰地观察钛种植体表面早期成骨的方式，也可客观地反映种植体表面性能对其表面早期成骨方式的影响。

Study on animal model of early osteogenesis on the surface of titanium implant

Objective To study the animal model suitable for the observation of early osteogenesis on the surface of ti-tanium implant. Methods Modify implants mode which the outer thread of the implant next to the osteotomy bone wall while the inter thread keep a certain distance to osteotomy bone wall was adopted in the 1-year-old male Beagle dogs. After extraction of all mandibular premolars and first molar bilaterally in the 4 dogs, 20 implants replaced the position. All sec-tions were stained for histological analysis. Results The surgical wound in the 4 dogs healed by first intention. The tita-nium implants have good stability. The formation of the new bone, which include the contact osteogenesis and distance osteogenesis, was observed as it progressed not only in the surface of the osteotomy bone wall but also in the surface of the implants. Conclusion The established animal model is suitable for the observation of both early osteogenesis in implant and the influences of implant surface properties to the early osteogenesis.