慢性支气管炎、肺气肿、肺心病患者血浆内皮素1、一氧化氮与血气变化的研究

目的：探讨慢性支气管炎（慢支）、慢性阻塞性肺气肿（肺气肿）、慢性肺源性心脏病（肺心病）患者不同时期血浆内皮素1（ET-1）、一氧化氮（NO）及动脉血气的变化，为临床观察病情、评估预后、探讨新的治疗手段提供依据。方法：慢支、肺气肿、肺心病患者均空腹抽静脉血检测血浆ET-1、NO；另抽取动脉血检测血气。三组间对比，并与正常组对照。结果：肺气肿、肺心病患者血浆内皮素增高，血气指标异常．且由慢支发展到肺气肿、肺心病时血浆内皮素逐渐增高、动脉血氧分压（PaO2）渐降低，二氧化碳分压（PaCO2）渐增高，NO逐渐降低。结论：慢支发展为肺气肿、肺心病时，血浆ET1、PaCO2逐渐增高；N0、pH、PaO2逐渐降低。

Research of Plasma Endothelin-1 ,Nitrousoxide,Blood Gas Analysis,and Blood Viscosity in Patients with Chronic Bronchitis ,Pulmonary Emphysema and Pulmonary Heart Disease

Objective:To explore the change of plasma endothelin-1(ET-1),nitrousoxide(NO),blood gas analysis and blood viscosity in patients with chronic bronchitis,pulmonary emphysema and pulmonary heart disease at different period.And to search the oretic basis for obsearving clinical change,judging prognosis and new therapeutics.Methods:Vein blood was pumped from the patients with chronic bronchitis,pulmonary emphysema and pulmonary heart disease,then testing plama ET-1 and NO,artery blood was pumped for blood gas analysis.A contrastive study was performed among two groups and control group.Results:In pulmonary emphysema and pulmonary heart disease patients,the ET-1 level were higer,the indexes of blood gas analysis was abnormal.From pulmonary emphysema to pulmonary heart disease,the ET-1 and PaCO_2 tended to increase,PaO_2 tended to decrease.From chronic bronchitis to pulmonary emphysema and pulmonary heart disease,NO tended to decrease.Conclusion:When chronic bronchitis develope into pulmonary emphysema or pulmonary heart disease,the airway obstruction lead to hypoxia progress,then ET-1,PaCO_2 tend to increase and NO,pH,PaO_2 tend to decrease.