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Therapy of Core Binding Factor Acute Myeloid Leukemia: Incremental Improvements Toward Better Long-Term Results
Authors:Vijaya Raj Bhatt  Hagop Kantarjian  Jorge E Cortes  Farhad Ravandi  Gautam Borthakur
Institution:1. Leukemia Department, M.D. Anderson Cancer Center, Houston, TX;2. Staten Island University Hospital, New York, NY;1. Beta-Cell Biochemistry Laboratory, John D. Dingell VA Medical Center, and Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI 48201, USA;2. Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico Medical School Campus, Post Office Box 365067, San Juan, PR 00936-5067, USA;3. School of Biomedical Sciences, Curtin Health Sciences Innovation Research Institute, Curtin University, Perth, WA 6845, Australia;1. Service d’hématologie, CHU de Besançon, 1, boulevard Fleming, 25030 Besançon cedex, France;2. Inserm UMR1098, bâtiment Inserm, 20, rue Françoise-Dolto, 25000 Besançon, France;3. SFR FED 4234, bâtiment Inserm, université de Franche-Comté, 20, rue Françoise-Dolto, 25000 Besançon, France;4. Plateforme de biomonitoring, EFS Bourgogne Franche-Comté, 2, boulevard Fleming, 25020 Besançon cedex, France;5. Centre d’investigation clinique en biothérapies 506, CHU de Besançon, 1, boulevard Fleming, 25030 Besançon cedex, France;6. Activité d’ingénierie et de thérapie cellulaire, EFS Bourgogne Franche-Comté, 2, boulevard Fleming, 25020 Besançon cedex, France;7. Laboratoire HLA, EFS Bourgogne Franche-Comté, 2, boulevard Fleming, 25020 Besançon cedex, France;8. Service de bactériologie, CHU de Besançon, 1, boulevard Fleming, 250030 Besançon cedex, France;3. From the Institute of Pharmacology and Toxicology and;4. the Core Unit Mass Spectrometry and Proteomics, Medical Faculty, Ulm University, 89081 Ulm, Germany,;5. the Division of Molecular Genetics, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany, and;6. the Diaxonhit, 63–65 Boulevard Masséna, 75013 Paris, France;1. Massachusetts General Hospital, Zero Emerson Place, Suite 118, Boston, MA 02114, USA;2. Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA
Abstract:BackgroundDespite being considered as good prognostic acute myelogenous leukemia (AML), the long-term survival rate in core binding factor (CBF) AML leaves room for substantial improvement.Materials and MethodsWe reviewed relevant English language literature related to treatment of CBF AML available in PubMed. Review also included meeting abstracts.ResultsMulticycle high dose cytarabine in consolidation improves remission duration but larger groups report overall survival in the range of 40% to 50% at 5 years or longer.ConclusionsConcerted effort is needed toward improving outcomes in CBF AML through clinical trials and risk-adapted approach.
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